Detection of Early Esophageal Squamous Neoplasia
关键词
抽象
描述
Probe-based confocal laser endomicroscopy (pCLE; Cellvizio, Mauna Kea Technologies, Paris, France) is a newly developed endoscopic device and has shown its value for diagnosing Barrett's esophagus, colonal polyps and etc. However, none research has focus on early esophageal squamous neoplasia until now. Previous diagnosis of early esophageal neoplasia is based on the lugol staining which is time wasting and have many adverse events.Other researches have suggested virtual chromoendoscopys are beneficial for screening esophageal tumors. Therefore, the aim of the present study is 1.To investigate the diagnosing value of pCLE for early esophageal squamous neoplasia according to the surface maturation scoring(SMS) diagnostic criteria and 2. To assess the detection rate of early esophageal squamous neoplasia by virtual chromoendoscopy(I-SCAN).
日期
| 最后验证: | 06/30/2013 |
| 首次提交: | 07/23/2013 |
| 提交的预估入学人数: | 07/23/2013 |
| 首次发布: | 07/25/2013 |
| 上次提交的更新: | 07/23/2013 |
| 最近更新发布: | 07/25/2013 |
| 实际学习开始日期: | 06/30/2013 |
| 预计主要完成日期: | 11/30/2013 |
| 预计完成日期: | 11/30/2013 |
状况或疾病
相
手臂组
| 臂 | 干预/治疗 |
|---|---|
| pCLE examination pCLE is used to distinguish the suspected lesions detected by I-SCAN in esophagus |
资格标准
| 有资格学习的年龄 | 50 Years 至 50 Years |
| 有资格学习的性别 | All |
| 取样方式 | Non-Probability Sample |
| 接受健康志愿者 | 是 |
| 标准 | Inclusion Criteria: - Patients aged between 50 and 80 years old - Patients undergo screening endoscopy or histologically verified esophageal squamous intraepithelial neoplasia before. Exclusion Criteria: - Advanced esophageal, gastric or duodenal cancer - History of upper GI tract surgery - Coagulopathy or acute GI bleeding - Pregnant or breast-feeding (for females) - Impaired renal function - Allergy to fluorescein sodium - Inability to provide informed consent. |
结果
主要结果指标
1. The diagnostic accuracy of pCLE on early esophageal squamous neoplasia [6 month]
