Detection of Epileptiform Activity in Severe Preeclampsia
关键词
抽象
描述
Preeclampsia constitutes a heterogeneous multisystemic disorder defined by the new onset of hypertension and proteinuria after 20 weeks of gestation.1 The incidence of preeclampsia in Switzerland is estimated at 2.31 % of pregnancies (95% CI 1.62-3.28%), about 1'911 cases/year can be expected to occur on the national level. Preeclampsia and eclampsia are considered a continuum in the hypertensive disorders of pregnancy. When convulsions or coma occur in addition to hypertension the condition is referred to as eclampsia. Up to 2-3% of severely preeclamptic women will have eclampsia,4 with a consecutive mortality rated between 0-14%.5 The diagnosis of preeclampsia is challenging, because of clinical heterogenity, especially at early stages. Until recently no routine laboratory test or biological marker other than presenting clinical symptoms such as severe headache or arterial hypertension, decreased plasmatic thrombocyte count and proteinuria were available for diagnostic purposes.
The only curative treatment of severe preeclampsia and eclampsia consists of delivery of fetus and placenta. Since the 2002 Magpie trial, the mainstay of eclampsia prevention in severely preeclamptic patients relies on the prophylactic use of intravenous magnesium, either when prompt delivery can be performed, or if it has to be delayed for fetal reasons. Obviously, eclampsia prevention is critical, considering that eclampsia onset can occur pre, intra, or postpartum. Hereby the prophylactic magnesium treatment is mostly maintained throughout a period of several days before and after delivery of the fetus and placenta, as up today there is no reliable clinical or diagnostic approach to predict the risk of eclamptic seizures.
The actual gold standard in high-risk maternities is to assess clinical symptoms as described above and perform newer laboratory essays, in order to estimate the parturient's risk for preeclamptic complications. Insofar changes in serum levels of fms-like tyrosine kinase-1 (sFlt-1) and placental growth factor (PGIF) were lately revealed and have been currently approved as diagnostic aid in preeclampsia. Circulating maternal serum levels of sFlt-1 are increased, and PGIF are decreased in preeclampsia. As an antagonist of PGIF and vascular endothelial growth factor, sFlt-1 causes vasoconstriction and endothelial damage. Noteworthy a sFlt-1:PIGF ratio lower than 38 can be used as to predict a short-term absence of preeclampsia in women with suspect clinical symptoms.
Interestingly novel knowledge points to a strong link in between plasmatic steroid hormones and epilepsy, with strong animal data pointing towards a higher epileptogenic potential in high estrogenic states; whereas androgens, namely progesterone seem to induce a protective state through agonism on extrajunctional GABAA receptors.
EEG slopes are good markers for epileptiform activity. EEG changes have been reported in eclampsia and in severe preeclampsia, with differences also reported between severe preeclampsia and eclampsia.Recently, slow waves most frequently localized in the occipital lobe, as well as spike discharges in EEG, were reported as warning signs of deterioration of brain function in preeclampsia or eclampsia. Neither have electroencephalic correlates of sFlt-1, PGIF or hormonal states been investigated in preeclampsia. EEG is not in routine use for convulsive risk assessment in maternity wards, when preeclampsia screening is performed. One of the reasons might be that performing EEGs is time consuming and involves significant human resources for urgent EEG analysis. These resources might be lacking even in tertiary hospitals. Novel reliable, noninvasive and technically easy to perform simplified EEG methods have become available, these are especially in use during anesthesia for detection of clinically silent epileptic potentials.
日期
| 最后验证: | 12/31/2018 |
| 首次提交: | 04/02/2018 |
| 提交的预估入学人数: | 04/02/2018 |
| 首次发布: | 04/10/2018 |
| 上次提交的更新: | 01/21/2019 |
| 最近更新发布: | 01/23/2019 |
| 实际学习开始日期: | 12/31/2018 |
| 预计主要完成日期: | 12/19/2019 |
| 预计完成日期: | 02/29/2020 |
状况或疾病
干预/治疗
Drug: Preeclampsia
相
手臂组
| 臂 | 干预/治疗 |
|---|---|
| Preeclampsia Women aged 18-45 years
Confirmed pregnancy > 30 weeks of gestation
Singleton or multiple pregnancies
Admission in maternity of the Women's hospital with clinically suspected signs of severe preeclampsia:
Systolic blood pressure >140 mmHg or diastolic pressure > 90 mmHg and
Proteinuria > 0.3 grams in a 24-hour urine or protein:creatinine ratio >0.3 or
Signs of end-organ dysfunction (platelet count < 100'000G/l, serum creatinine >110 mg/l, or doubling of the serum creatinine, elevated serum transaminases to twice normal concentration) | Drug: Preeclampsia Baseline EEG measurement will be performed for 5 minutes before intravenous magnesium administration will start as defined by the administration scheme of the Women's Hospital of the Bern University Hospital. After completion of the bolus infusion and at the beginning of the maintenance infusion of magnesium the second EEG measure will be performed for another 5 minutes. After 4 hours of intravenous magnesium treatment the plasmatic magnesium concentration is expected to be at a steady-state. A third 5-minute measure will be performed at this time point. |
资格标准
| 有资格学习的年龄 | 18 Years 至 18 Years |
| 有资格学习的性别 | Female |
| 取样方式 | Probability Sample |
| 接受健康志愿者 | 是 |
| 标准 | Inclusion Criteria: 1. Confirmed pregnancy > 30 weeks of gestation 2. Singleton or multiple pregnancies 3. Admission in maternity of the Women's hospital with clinically suspected signs of severe preeclampsia: - Systolic blood pressure >140 mmHg or diastolic pressure > 90 mmHg and - Proteinuria > 0.3 grams in a 24-hour urine or protein:creatinine ratio >0.3 or - Signs of end-organ dysfunction (platelet count < 100'000G/l, serum creatinine >110 mg/l, or doubling of the serum creatinine, elevated serum transaminases to twice normal concentration) Exclusion Criteria: 1. Lack of patient's informed consent 2. Active labor 3. Eclampsia 4. Hypertensive crisis as defined by Systolic blood pressure > 210 mmHg or diastolic pressure > 120 mmHg 5. Known epilepsy 6. Posterior reversible encephalopathy syndrome 7. Antiepileptic medication (except magnesium sulfate) 8. Reported or admitted medication or substance abuse (street drugs, opiates, benzodiazepines, alcohol) 9. Known neurologic condition with previously pathologic diagnostic imaging or EEG 10. Severe fetal malformations (abdominal: gastroschisis & omphalocele, tracheoesophageal fistula, cerebral: brain malformations included in the category of cephalic disorders, pulmonary: lung hypoplasia, cardiac: congenital heart disease) 11. Preceding rupture of membranes 12. Non-German and non-French speaking parturient |
结果
主要结果指标
1. Epileptiform activity [0-4h after Magnesium Sulfate administration]
次要成果指标
1. Biological correlates to epileptiform activity [72h after inclusion]
2. Demographics of mother and infant [72h after inclusion]
