Development and Validation of a Tumour Oxygenation Monitoring Probe
关键词
抽象
描述
Tumour hypoxia is feature common to most solid tumours, with significant implications in tumour aggressiveness, metastatic potential and response to therapy. Tumour oxygenation monitoring is likely, therefore, to provide a valuable adjunct in risk stratification and treatment response monitoring.
Diffuse reflectance spectroscopy (DRS) utilises the differing absorption of oxygenated as compared to deoxygenated haemoglobin to provide an accurate measure of tissue oxygenation.
This project aims to develop and validate a tissue oxygenation probe for cancer monitoring. Using the clinical paradigms of rectal and breast cancer, anonymised MRIs of cancer sufferers will guide simulations of tissue optical properties to develop a DRS probe. The 3D reconstructed sans will then be used to 3D print tissue phantom models on which the DRS probe will be validated against reference bench top analysers.
日期
| 最后验证: | 07/31/2019 |
| 首次提交: | 05/21/2019 |
| 提交的预估入学人数: | 06/09/2019 |
| 首次发布: | 06/10/2019 |
| 上次提交的更新: | 08/12/2019 |
| 最近更新发布: | 08/14/2019 |
| 实际学习开始日期: | 08/08/2019 |
| 预计主要完成日期: | 05/31/2020 |
| 预计完成日期: | 05/31/2020 |
状况或疾病
干预/治疗
Device: DRS probe
相
手臂组
| 臂 | 干预/治疗 |
|---|---|
| Breast Cancer Anonymised MRI scans (pre-therapy) of locally advanced breast cancer sufferers. | |
| Rectal Cancer Anonymised MRI scans (pre-therapy) of locally advanced rectal cancer sufferers. |
资格标准
| 有资格学习的年龄 | 18 Years 至 18 Years |
| 有资格学习的性别 | All |
| 取样方式 | Non-Probability Sample |
| 接受健康志愿者 | 是 |
| 标准 | Inclusion Criteria: - MRIs from Breast or Rectal Cancer patients (10 of each) - Locally advanced Cancers (Stage 2 or 3) - Patients who went on to receive neoadjuvant chemoradiotherapy. - Anonymised scans Exclusion Criteria: - MRIs from patients under the age of 18, or older than 99 years old will be excluded. - MRIs from patients who did not receive neoadjuvant therapy for cancer will be excluded. |
结果
主要结果指标
1. Oxygenation correlation [During Intervention: The DRS probe (intervention) and reference (control) measurements will take place within one hour]
