Dexmedetomidine for Sepsis in ICU Randomized Evaluation Trial
关键词
抽象
日期
最后验证: | 01/31/2017 |
首次提交: | 12/25/2012 |
提交的预估入学人数: | 01/01/2013 |
首次发布: | 01/03/2013 |
上次提交的更新: | 02/24/2017 |
最近更新发布: | 02/27/2017 |
实际学习开始日期: | 12/31/2012 |
预计主要完成日期: | 12/31/2015 |
预计完成日期: | 12/31/2015 |
状况或疾病
干预/治疗
Drug: Dexmedetomidine
相
手臂组
臂 | 干预/治疗 |
---|---|
Active Comparator: Dexmedetomidine administer dexmedetomidine (0.1-0.7ug/kg/h) from the beginning of ICU treatment | |
Active Comparator: non-Dexmedetomidine administer sedatives except Dexmedetomidine |
资格标准
有资格学习的年龄 | 20 Years 至 20 Years |
有资格学习的性别 | All |
接受健康志愿者 | 是 |
标准 | Inclusion Criteria: - adult - transferred to ICU - anticipation of a need for mechanical ventilation at least 24 hours Exclusion Criteria: - sever chronic liver disease (Child B or C) - acute myocardial infarction, heart disease (NYHA 4) - Drug dependence, alcoholism - Psychological illness, severe cognitive dysfunction - patients who have allergy for dexmedetomidine - attending physician's decision |
结果
主要结果指标
1. mortality [on 28 days]
2. duration of mechanical ventilation [up to 28 days]
次要成果指标
1. length of stay in the ICU [up to 28 days]
2. length of stay in the hospital [up to 28 days]
3. Evaluation of restlessness and delirium [up to 28 days in the ICU]
4. Evaluation of cognitive function [on 28 days or on the day of discharge]
5. Occurrence of arrythmia or myocardial ischemia [up to 28 days in the ICU]
6. Renal function [up to 28 days in the ICU]
7. infection control [within 28 days until discharge]
8. inflammation marker [for 14days]
9. organ failure control [up to 28 days in the ICU]
10. coagulopathy control [for 14 days]
11. nutrition control [up to 28 days in the ICU]
12. sedation control [up to 28 days in the ICU]