Dietary Intake of Alpha-linolenic Acid in Elderly
关键词
抽象
描述
There is growing evidence that diets high in long chain n-3 polyunsaturated fatty acids (PUFA) decrease the risk of fatal ischemic heart disease.Both epidemiologic studies and clinical trials demonstrate substantial cardioprotective effects of alpha linolenic acid (ALA) from vegetable oils.However, little is known about the relation of the dietary intake of ALA with ischemic heart disease among older adults.In this study, elderly volunteers will be asked to ingest a supplement of a vegetable oil providing 1g of ALA, or an equivalent amount of linoleic acid as sunflower oil, for a diet period of 6 weeks.Serum samples will be collected before the dietary intervention and 6 weeks later.Plasma biomarkers of inflammatory, lipid cardiovascular risk factors and serum and red cell membrane fatty acid composition will be determined on all samples.
日期
| 最后验证: | 12/31/2016 |
| 首次提交: | 01/09/2017 |
| 提交的预估入学人数: | 01/17/2017 |
| 首次发布: | 01/18/2017 |
| 上次提交的更新: | 01/17/2017 |
| 最近更新发布: | 01/18/2017 |
| 实际学习开始日期: | 10/31/2006 |
| 预计主要完成日期: | 01/31/2011 |
| 预计完成日期: | 11/30/2011 |
状况或疾病
干预/治疗
Dietary Supplement: Rapeseed arm
Dietary Supplement: Sunflower arm
相
手臂组
| 臂 | 干预/治疗 |
|---|---|
| Placebo Comparator: Sunflower arm Participants were supplied with the usual diet of the hospital, daily enriched with 17.5g fat as follows during 42 days: 10 g of sunflower oil (with a high content in linoleic acid) were added into the dinner soup and 7.5g delivered through a 12.5g portion of margarine made with sunflower oil (60% fat) that replaced butter on the breakfast toasts. | Dietary Supplement: Sunflower arm Placebo comparator arm : Dietary Supplement: sunflower oil supplementation (10g per day) and margarine with a high level of inoleic acid (12.5g per day) during 42 days. |
| Active Comparator: Rapeseed arm Participants were supplied with the usual diet of the hospital, daily enriched with 17.5g fat as follows during 42 days: 10 g of rapeseed oil (with a high content in alpha-linolenic acid) were added into the dinner soup and 7.5g delivered through a 12.5g portion of margarine made with rapeseed oil (60% fat) that replaced butter on the breakfast toasts. | Dietary Supplement: Rapeseed arm Active comparator arm : Dietary Supplement: rapeseed oil supplementation (10g per day) and margarine with a high level of alpha-linolenic acid (12.5g per day) during 42 days. |
资格标准
| 有资格学习的年龄 | 65 Years 至 65 Years |
| 有资格学习的性别 | All |
| 接受健康志愿者 | 是 |
| 标准 | Inclusion Criteria: - Elderly patients over 65 years old exhibiting clinical indices of cardiovascular disease - Male or female - Subjects who were hospitalized in the Geriatric Unit of the Emile Roux Hospital (AP-HP) - MMSE (Mini Mental State Examination)score > or = 15 - Supervision available for study medication - Able to ingest oral diet Exclusion Criteria: - Patients unable to understand the objectives of the dietary intervention - Patients in paliative care - Patients receiving supplement diets |
结果
主要结果指标
1. Effects of diet supplementation on fatty acid composition in serum and red cell membrane phospholipids, at the end of dietary period [6 weeks]
次要成果指标
1. Pulse wave velocity (PWV) [6 weeks]
2. Others [6 weeks]
