Effect of Aerobic Exercise Associated With Abdominal Laser Therapy
关键词
抽象
描述
The adipose tissue is the main energetic reserve, being constituted by adipocytes, cells that accumulate lipids inside its cytoplasm, in the form of triglycerides.
Fat deposition can occur both in the subcutaneous compartment and in the visceral compartment and is the result of a positive energy balance in which there is an imbalance between the amount of calories consumed and the amount of calories expended. Thus, an excess of energy storage occurs in the form of triglycerides in adipose tissue, which results from a sedentary lifestyle and a diet based on lipid rich nutrients. When fat deposition occurs in abdominal adipose tissue may favor the development of metabolic disorders.
Recently the effectiveness of an innovative physiotherapeutic intervention - low power laser therapy (LLLT) - on adipose tissue has been studied. This therapeutic modality stimulates cytochrome C oxidase, causing the release of nitric oxide, increased mitochondrial membrane potential and adenosine triphosphate (ATP) synthesis and the transient increase of reactive oxygen species (ROS). It is proposed that ROS creates temporary pores in the adipocyte membrane, allowing the release of its lipid content. It is also suggested that a regulation of cAMP occurs, which stimulates the lipolytic cascade, converting the triglycerides to fatty acids and glycerol. In this way, low level laser therapy seems to aid in the reduction of adiposity and in the decrease of cholesterol and triglycerides serum levels . In addition, it assists in the reduction of the inflammatory process related to obesity, by reducing the pro-inflammatory cytokines.
The aerobic exercise, due to its low-moderate intensity, enhances the stimulation of lipolysis, by decreasing plasma insulin concentration and elevating the level of catecholamines. In this way, it influences the lipid metabolism, seeming to improve the lipid profile, through the degradation of the triglycerides as energetic substrate. In addition, the regular practice of physical exercise seems to promote a decrease in the inflammation state due to metabolic changes, through the reduction of pro-inflammatory cytokines, namely interleukin-6 and, consequently, C-reactive protein.
The application of low level laser therapy in the abdominal region enhances the release of fat acids and glycerol into the bloodstream, increasing the availability of the substrate for muscle energy consumption. However, if they are not used as energy, free circulating fat acids may bind to glycerol and potentiate, again, the accumulation of triglycerides in abdominal adipocytes. Thus, aerobic exercise seems to be a good option in the fight against this re-esterification, since it is expected that the resulting fat acids will be converted to acetyl-CoA, entering the Krebs cycle, being used as energy source during aerobic exercise.
日期
最后验证: | 02/28/2018 |
首次提交: | 03/05/2018 |
提交的预估入学人数: | 03/05/2018 |
首次发布: | 03/11/2018 |
上次提交的更新: | 03/05/2018 |
最近更新发布: | 03/11/2018 |
实际学习开始日期: | 11/19/2016 |
预计主要完成日期: | 05/19/2017 |
预计完成日期: | 06/19/2017 |
状况或疾病
干预/治疗
Device: Experimental group 1
Device: Aerobic Exercise
Device: Low level laser therapy without power
相
手臂组
臂 | 干预/治疗 |
---|---|
Experimental: Experimental group 1 This group performed aerobic exercise just after low level laser therapy in the abdominal region with eight electrodes distributed in line. | Device: Experimental group 1 Low level laser therapy protocol - The low level laser therapy protocol was performed in dorsal decubitus, with the head elevated at 45º. The electrodes were placed in line, in the abdominal region. The low level laser therapy device has a length of about 940nm, using 8 pads, which have 64 diodes, each one with 100mW. The duration of the application was established in 8 minutes. |
Experimental: Experimental group 2 This group performed aerobic exercise just after low level laser therapy in the abdominal region with eight electrodes distributed in line, but low level laser therapy device was switched off. | |
Placebo Comparator: Placebo group Low level laser therapy without power. This group performed the low level laser therapy protocol, but low level laser therapy device was switched off. |
资格标准
有资格学习的年龄 | 18 Years 至 18 Years |
有资格学习的性别 | Female |
接受健康志愿者 | 是 |
标准 | Inclusion Criteria: - age between 18 and 25 years. - BMI between 18,5Kg/m2 and 29,9Kg/m2 - consider presenting abdominal fat Exclusion Criteria: - pregnant or intending to be in a period of 9 months - participants with smoking habits - participants with neoplasias, metabolic dysfunctions, renal pathologies, dermatological alterations - participants with electronic devices - participants with a condition that makes it impossible to practice physical exercise (disabling skeletal muscle pathologies and severe cardiorespiratory pathologies) - participants under the effect of beta-blockers or other drugs which influence heart rate - participants submitted to other fat reduce procedure |
结果
主要结果指标
1. Change in glycerol concentration [10 minutes before the intervention and 5 minutes after the intervention]
2. Change in CRP concentration [10 minutes before the intervention and 5 minutes after the intervention]
3. Change in lipid profile (LDL, HDL and triglyceride concentrations) [10 minutes before the intervention and 5 minutes after the intervention]