Effect of Flavonoids on Gut Permeability in Cyclists
关键词
抽象
日期
| 最后验证: | 09/30/2018 |
| 首次提交: | 01/29/2018 |
| 提交的预估入学人数: | 02/01/2018 |
| 首次发布: | 02/08/2018 |
| 上次提交的更新: | 10/09/2018 |
| 最近更新发布: | 10/14/2018 |
| 实际学习开始日期: | 09/13/2018 |
| 预计主要完成日期: | 02/27/2019 |
| 预计完成日期: | 07/30/2019 |
状况或疾病
干预/治疗
Drug: Low flavonoid beverage
Drug: High flavonoid beverage
相
手臂组
| 臂 | 干预/治疗 |
|---|---|
| Placebo Comparator: Low flavonoid beverage Subjects will consume 310 milliliters per day of a dairy-based, low flavonoid, sports nutrition recovery beverage 14 days. | Drug: Low flavonoid beverage A low flavonoid, sports nutrition recovery beverage will be prepared from milk (78%), sugar (8.6%), maltodextrin (8.6%), placebo blueberry powder (2.4%), alkalized cocoa powder (1.6%), and whey protein isolate (0.6%). The beverage will contain approximately 5mg flavonoids per serving. |
| Active Comparator: High flavonoid beverage Subjects will consume 310 milliliters per day of a dairy-based, high flavonoid, sports nutrition recovery beverage 14 days. | Drug: High flavonoid beverage A high flavonoid, sports nutrition recovery beverage will be prepared from milk (78%), sugar (8.6%), maltodextrin (8.6%), blueberry powder (2.4%), cocoa powder (1.6%), green tea extract (0.1%) and whey protein isolate (0.6%). The beverage will contain approximately 620 mg flavonoids per serving. |
资格标准
| 有资格学习的年龄 | 18 Years 至 18 Years |
| 有资格学习的性别 | All |
| 接受健康志愿者 | 是 |
| 标准 | Inclusion Criteria: - Male or female of any race or ethnicity between 18 to 49 years of age - Competed in a road race or triathlon in past 12 months - Free of chronic disease and GI conditions - Train at least 3 times per week, 1 hour at a time on average - Willing to prepare and consume provided pre-workout beverage daily - Maintain weight (no more/less than 5 kg change) - Willing to avoid consumption of high flavonoid foods/supplements, large dose vitamin and mineral supplements, and NSAIDs or other medications known to affect inflammation during study period - Willing to provide urine, stool, and blood samples Exclusion Criteria: - Age <18 or >50 years - Medical history of heart disease, hypertension, diabetes, Crohn's disease, IBS, colitis, celiac disease, inflammatory or autoimmune disease, and lactose intolerance - Uncontrolled hypertension: diastolic blood pressure >95 mm Hg or systolic blood pressure >160 mm Hg - For women: pregnancy, breast feeding or postpartum <6 months - Food allergies or restrictions to treatment/placebo beverages - Chronic use of NSAIDs - Consumption of flavonoid supplements <1 month prior to study start - Antibiotic use <3 months prior to study start - Other conditions (medical, psychiatric, or behavioral) that may present a safety hazard to the participant or interfere with study participation, as determined by the principal investigators |
结果
主要结果指标
1. Urinary lactulose:mannitol ratio by gas chromatography [Three weeks]
2. Plasma intestinal fatty acid binding protein (i-FABP) by ELISA [Three weeks]
次要成果指标
1. Fecal calprotectin by ELISA [Three weeks]
2. Urinary sucralose:mannitol ratio by gas chromatography [Three weeks]
3. Serum soluble tumor necrosis factor (TNFa) by ELISA [Three weeks]
4. Serum soluble interleukin-6 (IL-6) by ELISA [Three weeks]
5. Serum soluble interleukin-10 by ELISA [Three weeks]
6. Serum endotoxin by ELISA. [Three weeks]
7. Distance ridden in time trial [One Day]
8. Rating of perceived exertion by questionnaire. [One Day]
