Effect of Ketamine Addition to Lidocaine in Rhinoplasty
关键词
抽象
描述
In rhinoplasty operations local infiltration anesthesia uses for surgery insight and patient comfort. The investigators designed this study to prolonged the time of infiltration block and preventive analgesia. So, before operation, study drugs will infiltrate to the submucosa of intranasal cavity. Then, surgeon and patient satisfaction, postoperative analgesic demand, postoperative pain scores and side effects will determine.
日期
| 最后验证: | 03/31/2013 |
| 首次提交: | 03/27/2013 |
| 提交的预估入学人数: | 04/07/2013 |
| 首次发布: | 04/08/2013 |
| 上次提交的更新: | 04/07/2013 |
| 最近更新发布: | 04/08/2013 |
| 实际学习开始日期: | 12/31/2012 |
| 预计主要完成日期: | 01/31/2013 |
| 预计完成日期: | 02/28/2013 |
状况或疾病
干预/治疗
Drug: Group L (number of participants=30)
Drug: Group K (number of participants=30)
Drug: Group S (number of participants=30)
相
手臂组
| 臂 | 干预/治疗 |
|---|---|
| Active Comparator: Group L (number of participants=30) After standard anesthesia induction and before surgery, patients will receive submucosal infiltration of 12 mL lidocaine 2%, 1mg/kg into nasal cavity. | Drug: Group L (number of participants=30) 12 mL lidocaine 2% 1mg/kg |
| Active Comparator: Group K (number of participants=30) After standard anesthesia induction and before surgery, patients will receive submucosal infiltration of 12 mL ketamine 0.5 mg/kg plus lidocaine 2% 1 mg/kg of the intranasal cavity. | Drug: Group K (number of participants=30) ketamine 0.5 mg/kg + Lidocaine 2% 1 mg/kg in total volume of 12 mL |
| Placebo Comparator: Group S (number of participants=30) After standard anesthesia induction and before surgery, patients will receive submucosal infiltration of saline 12 mL into intranasal cavity. | Drug: Group S (number of participants=30) 12 mL saline (0.9% isotonic solution) |
资格标准
| 有资格学习的年龄 | 18 Years 至 18 Years |
| 有资格学习的性别 | All |
| 接受健康志愿者 | 是 |
| 标准 | Inclusion Criteria: - Patients scheduled for elective rhinoplasty operation under general anesthesia - Patients with ASA (American Society of Anesthesiology) class I - Patients between 18-50 years old Exclusion Criteria: - Age <18 and >50 - ASA > II - Preexisting neurological or psychiatric illness - Systemic diseases (diabetes mellitus, hypertension, coronary heart disease...) - Having a history of chronic pain and receiving chronic analgesia therapy - Having a history of drug abuse |
结果
主要结果指标
1. Postoperative pain scores on the Visual Analogue Scale [24 hours]
次要成果指标
1. Patient satisfaction [24 hour]
2. Analgesic demand [24 hour]
其他成果措施
1. Number of participants with adverse effects as a measure of safety and tolerability [24 hour]
