Effect of Soft Fruit on Postprandial Blood Glucose
关键词
抽象
描述
Sixteen overweight/obese volunteers from the Aberdeen area will be recruited into a randomised controlled study. Volunteers will be randomised into four groups matched for BMI and age and given 200 grams of blackcurrants (which contain anthocyanins) or greencurrants (which naturally contain no anthocyanins), followed by an OGTT.
The consumption of the currants will be followed by an oral glucose tolerance test (OGTT) with Polycal (complex carbohydrate) or glucose (simple carbohydrate) as the carbohydrate load.
There will be a one week minimum wash out period between each intervention. All interventions will be randomised and blinded as far as possible in a cross-over design where the volunteers are acting as their own control. The volunteers will be asked to consume a low phytochemical diet three days prior to taking the currants all occasions. In addition, they will be asked to record what they ate over the same period in a simple food diary.
The following intervention will be carried out on 16 overweight/obese male/postmenopausal female non-smoker volunteers:
1. Control: sugar matched (matched to currant sugar content) water with polycal (complex carbohydrate load)
2. Blackcurrants (which contain anthocyanins; 200grams) with polycal (complex carbohydrate load)
3. Blackcurrants (which contain anthocyanins; 200grams) with glucose (simple carbohydrate load)
4. Greencurrants (which naturally contain no anthocyanins; 200grams) with polycal (complex carbohydrate load)
Note: the polycal will contain the equivalent glucose load as given in intervention 3 assuming complete hydrolysis of all carbohydrates.
日期
| 最后验证: | 03/31/2019 |
| 首次提交: | 11/10/2014 |
| 提交的预估入学人数: | 11/12/2014 |
| 首次发布: | 11/13/2014 |
| 上次提交的更新: | 04/15/2019 |
| 最近更新发布: | 04/16/2019 |
| 实际学习开始日期: | 10/31/2014 |
| 预计主要完成日期: | 08/31/2019 |
| 预计完成日期: | 08/31/2019 |
状况或疾病
干预/治疗
Dietary Supplement: Blackcurrants with polycal OGTT
Dietary Supplement: Greencurrants with polycal OGTT
Dietary Supplement: Blackcurrants with glucose OGTT
Dietary Supplement: Sugar matched water with polycal OGTT
相
手臂组
| 臂 | 干预/治疗 |
|---|---|
| Experimental: Sugar matched water with polycal OGTT Control: sugar matched (matched to currant sugar content) water with polycal
Blackcurrants (200grams) with polycal
Blackcurrants (200grams) with glucose
Greencurrants (200grams) with polycal Sixteen overweight/obese volunteers from the Aberdeen area will be recruited into a randomised controlled study. Volunteers will be randomised into four groups matched for BMI and age and given 200 grams of blackcurrants (which contain anthocyanins) or greencurrants (which naturally contain no anthocyanins), followed by an OGTT.
The OGTT will be carried out with glucose as a simple carbohydrate load or polycal as a complex carbohydrate load.
Volunteers will be randomised into four groups (n=4 per group). One week wash out between treatments | Dietary Supplement: Sugar matched water with polycal OGTT Sixteen overweight/obese volunteers from the Aberdeen area will be recruited into a randomised controlled study. Volunteers will be randomised into four groups matched for BMI and age and given 200 grams of blackcurrants (which contain anthocyanins) or greencurrants (which naturally contain no anthocyanins), followed by an OGTT.
The consumption of the currants will be followed by an oral glucose tolerance test (OGTT) with Polycal (complex carbohydrate) or glucose (simple carbohydrate) as the carbohydrate load.
The equivalent carbohydrate load will be standardised across the groups |
| Experimental: Blackcurrants with polycal OGTT Blackcurrants (200grams) with polycal
Blackcurrants (200grams) with glucose
Greencurrants ( 200grams) with polycal
Control: sugar matched (matched to currant sugar content) water with polycal
Sixteen overweight/obese volunteers from the Aberdeen area will be recruited into a randomised controlled study. Volunteers will be randomised into four groups matched for BMI and age and given 200 grams of blackcurrants (which contain anthocyanins) or greencurrants (which naturally contain no anthocyanins), followed by an OGTT.
The OGTT will be carried out with glucose as a simple carbohydrate load or polycal as a complex carbohydrate load as decribed above.
Volunteers will be randomised into four groups (n=4 per group). One week wash out between treatments | Dietary Supplement: Blackcurrants with polycal OGTT Sixteen overweight/obese volunteers from the Aberdeen area will be recruited into a randomised controlled study. Volunteers will be randomised into four groups matched for BMI and age and given 200 grams of blackcurrants (which contain anthocyanins) or greencurrants (which naturally contain no anthocyanins), followed by an OGTT.
The consumption of the currants will be followed by an oral glucose tolerance test (OGTT) with Polycal (complex carbohydrate) or glucose (simple carbohydrate) as the carbohydrate load.
The equivalent carbohydrate load will be standardised across the groups |
| Experimental: Blackcurrants with glucose OGTT Blackcurrants (200grams) with glucose
Greencurrants (200grams) with polycal
Control: sugar matched (matched to currant sugar content) water with polycal
Blackcurrants (200grams) with polycal
Sixteen overweight/obese volunteers from the Aberdeen area will be recruited into a randomised controlled study. Volunteers will be randomised into four groups matched for BMI and age and given 200 grams of blackcurrants (which contain anthocyanins) or greencurrants (which naturally contain no anthocyanins), followed by an OGTT.
The OGTT will be carried out with glucose as a simple carbohydrate load or polycal as a complex carbohydrate load as decribed above
Volunteers will be randomised into four groups (n=4 per group). One week wash out between treatments | Dietary Supplement: Blackcurrants with glucose OGTT Sixteen overweight/obese volunteers from the Aberdeen area will be recruited into a randomised controlled study. Volunteers will be randomised into four groups matched for BMI and age and given 200 grams of blackcurrants (which contain anthocyanins) or greencurrants (which naturally contain no anthocyanins), followed by an OGTT.
The consumption of the currants will be followed by an oral glucose tolerance test (OGTT) with Polycal (complex carbohydrate) or glucose (simple carbohydrate) as the carbohydrate load.
The equivalent carbohydrate load will be standardised across the groups |
| Experimental: Greencurrants with polycal OGTT Greencurrants (200grams) with polycal
Control: sugar matched (matched to currant sugar content) water with polycal
Blackcurrants (200grams) with polycal
Blackcurrants (200grams) with glucose
Sixteen overweight/obese volunteers from the Aberdeen area will be recruited into a randomised controlled study. Volunteers will be randomised into four groups matched for BMI and age and given 200 grams of blackcurrants (which contain anthocyanins) or greencurrants (which naturally contain no anthocyanins), followed by an OGTT.
The OGTT will be carried out with glucose as a simple carbohydrate load or polycal as a complex carbohydrate load as decribed above.
Volunteers will be randomised into four groups (n=4 per group). One week wash out between treatments. | Dietary Supplement: Greencurrants with polycal OGTT Sixteen overweight/obese volunteers from the Aberdeen area will be recruited into a randomised controlled study. Volunteers will be randomised into four groups matched for BMI and age and given 200 grams of blackcurrants (which contain anthocyanins) or greencurrants (which naturally contain no anthocyanins), followed by an OGTT.
The consumption of the currants will be followed by an oral glucose tolerance test (OGTT) with Polycal (complex carbohydrate) or glucose (simple carbohydrate) as the carbohydrate load.
The equivalent carbohydrate load will be standardised across the groups |
资格标准
| 有资格学习的年龄 | 21 Years 至 21 Years |
| 有资格学习的性别 | All |
| 接受健康志愿者 | 是 |
| 标准 | Inclusion Criteria: - Obese male or female (postmenopausal) healthy non-smoking volunteers (BMI over 25kg/m2) - Aged >21 and <70 years Exclusion Criteria: - Medical exclusion criteria - Chronic illness, including: - thromboembolic or coagulation disease - unregulated thyroid disease - kidney disease - hepatic disease - severe gastrointestinal disorders - pulmonary disease (e.g. chronic bronchitis, COPD) - diabetes - Alcohol or any other substance abuse - Eating disorders - Psychiatric disorders (including severe depression, lithium treatment, schizophrenia, severe behavioural disorders) - Non-postmenopausal women - Medication exclusion criteria - Oral steroids - Tricyclic antidepressants, neuroleptics - Anticoagulants - Digoxin and anti-arrhythmics - Chronic use of anti-inflammatories (e.g. high doses of aspirin, ibuprofen), Insulin, -Sulphonylureas, Thiazolidinediones (glitazones), metformin. - Anti-obesity medication e.g. Orlistat |
结果
主要结果指标
1. Plasma Glucose Area Under the Curve [Plasma was collected at -15, -10 and -5 (fasted) and at 15, 30, 45, 60, 90, 120, 150 and 300 min post currant ingestion]
次要成果指标
1. Plasma Insulin Area Under the Curve [Plasma was collected at -15, -10 and -5 (fasted) and at 15, 30, 45, 60, 90, 120, 150 and 300 min post currant ingestion]
