Effects of Onion Peel Extract on Endothelial Function
关键词
抽象
描述
Epidemiological studies have shown a rapid increase in the prevalence of overweight and obesity, not only in adults but also in children and adolescents, thus increasing the risk of early development of cardiovascular disease (CVD). Quercetin, found abundantly in onion, prevents the induction of endothelial dysfunction, superoxide production, and overexpression by angiotensin II in the rat aorta. Furthermore, in our previous study we showed that supplementation with quercetin-rich onion peel extract (OPE) influenced adipokine expression, thus addressing its modulatory effect on obesity-induced inflammation, and improved insulin resistance by alleviating the metabolic dysregulation of free fatty acids, suppressing oxidative stress, upregulating glucose uptake, and downregulating inflammatory gene expression. But there are limited studies on the relationship between quercetin supplementation and endothelial dysfunction in humans.
日期
最后验证: | 05/31/2014 |
首次提交: | 06/27/2014 |
提交的预估入学人数: | 06/30/2014 |
首次发布: | 07/01/2014 |
上次提交的更新: | 06/30/2014 |
最近更新发布: | 07/01/2014 |
实际学习开始日期: | 03/31/2013 |
预计主要完成日期: | 11/30/2013 |
预计完成日期: | 11/30/2013 |
状况或疾病
干预/治疗
Drug: Placebo
Drug: Onion peel extract
相
手臂组
臂 | 干预/治疗 |
---|---|
Placebo Comparator: Placebo Patients treated with placebo for 12 weeks | Drug: Placebo After randomization, placebo was treated for 12 weeks |
Experimental: Onion peel extract Patients treated with onion peel extract for 14 days | Drug: Onion peel extract After randomization, onion peel extract was treated for 12 weeks |
资格标准
有资格学习的年龄 | 20 Years 至 20 Years |
有资格学习的性别 | All |
接受健康志愿者 | 是 |
标准 | Inclusion Criteria: - age 20 to 60 years - BMI >23 kg/m2 - abdominal circumference > 90 cm in males or >85 cm in females Exclusion Criteria: - hypertension (>140/90 mmHg), - diabetes - any cardiovascular disease, - kidney disease, - thyroid disease - cerebrovascular disease - liver disease (bilirubin level >2 mg/dl) - pregnancy |
结果
主要结果指标
1. The difference of endothelial function [12 weeks after study drug treatment]
次要成果指标
1. The difference of EPC (endothelial progenitor cell) counts [12 weeks after study drugs treatment]
其他成果措施
1. The composite measure of change of blood pressure, heart rate, body weight and blood chemistry [up to 12 weeks]