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Effects of Tart Cherry Juice on the Body

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University of Delaware

关键词

抽象

Tart cherries are a rich source of antioxidants. Studies have shown that tart cherries exert anti-oxidative and anti-inflammatory properties. The purpose of this study is to learn about the effects of drinking tart cherry juice on cardiovascular and cognitive health.

描述

Thirty-seven older adults were randomly assigned to drink 16 oz per day of either tart cherry juice or placebo drink for 12 weeks. Blood and urine samples were collected at baseline and 12 weeks to assess biomarkers. Physical activity and 3-day diet records were also collected throughout the study.

日期

最后验证: 09/30/2016
首次提交: 09/19/2016
提交的预估入学人数: 10/02/2016
首次发布: 10/03/2016
上次提交的更新: 10/02/2016
最近更新发布: 10/03/2016
实际学习开始日期: 10/31/2014
预计主要完成日期: 04/30/2016
预计完成日期: 08/31/2016

状况或疾病

Cardiovascular Risk Factors
Age-Related Cognitive Decline

干预/治疗

Other: Tart cherry juice

Other: Placebo juice

-

手臂组

干预/治疗
Experimental: Tart cherry juice
Participants consumed 16 fl. oz of tart cherry juice daily for 12 weeks.
Other: Tart cherry juice
16 fl. oz of tart cherry juice
Placebo Comparator: Placebo juice
Participants consumed 16 fl. oz of placebo daily for 12 weeks.
Other: Placebo juice
16 fl. oz of placebo

资格标准

有资格学习的年龄 65 Years 至 65 Years
有资格学习的性别All
接受健康志愿者
标准

Inclusion Criteria:

• Age 65-80

Exclusion Criteria:

- Allergic to tart cherries

- Heavy smoker

- Taking medications that affect cognitive function

- History of neurological disorders

- History of traumatic brain injury

- History of stroke

- Clinical diagnosis of diabetes

- Clinical diagnosis of Alzheimer's Disease/Dementia

- GI disease

- Kidney disease

- Liver disease

- Cancer

结果

主要结果指标

1. Cognitive function [Baseline and 12 weeks]

Change from baseline in cognitive test performance at 12 weeks

次要成果指标

1. Cardiovascular risk factors [Baseline and 12 weeks]

Fasting blood samples were collected at baseline and 12 weeks. Change from baseline in cardiovascular risk factors including blood lipid profiles, atherogenic risk ratios, blood glucose, hemoglobin A1c, insulin, and blood pressure at 12 weeks.

2. Oxidative stress markers [Baseline and 12 weeks]

Fasting blood samples were collected at baseline and 12 weeks. Change from baseline in plasma 8-oxoguanine (ng/ml), plasma 8-hydroxy-2deoxy-guanosine (ng/mL), plasma hydroxynonenal (ng/ml), and plasma malondialdehyde (pmole/L) at 12 weeks.

3. Inflammatory markers [Baseline and 12 weeks]

Fasting blood samples were collected at baseline and 12 weeks. Change from baseline in plasma tumor-necrosis factor-α (pg/mL) and plasma high-sensitivity C-reactive protein (ng/mL) at 12 weeks.

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