Environmental Temperature and White Adipose Tissue in Cancer Patients
关键词
抽象
描述
Obesity is characterized by excessive white adipose tissue (WAT) that increases risk for disease. About 700 million adults are obese worldwide, designating the need of reducing excessive WAT in humans and subsequently the risk for disease. For this reason, previous research focused on the thermogenic capacity of white adipocytes in response to cold exposure. Cold exposure represents a main stimulus for increased thermogenic capacity in human white adipocytes, which may have an impact on body weight loss and subsequently on obesity phenomenon.
In a cohort of 202 cancer patients (male=126), who undertook a Positron Emission Tomography (PET/CT), we retrospectively investigated the association between Tenv and thermogenic capacity of subcutaneous WAT (dorsolumbar region near vertebrae L3 and abdominal region). These patients undertook a PET/CT examination in order to define their disease status. They were given instructions in advance to refrain from smoking, exercise and excessive muscle stressors 24-hour prior to their examination. On the day of the measurements they advised to transport themselves by car to the PET/CT Laboratory between 08:00 am to 12 pm, following at least a 6-hour fasting. Patients were first injected an appropriate dose of 18F-FDG (based on their body weight) and then they were remained in a sitting relaxed position within a quiet room of 22-24°C for 60 minutes. Following this period, patients undertook the PET/CT examination, which included on average eight bed positions, while four minutes scanning per bed position was used.
PET/CT imaging analysis for WAT activity (dorsolumbar region near vertebrae L3 and abdominal region) was performed by two independent trained physicians, using previous methodology.
日期
最后验证: | 06/30/2019 |
首次提交: | 07/24/2019 |
提交的预估入学人数: | 07/28/2019 |
首次发布: | 07/29/2019 |
上次提交的更新: | 07/28/2019 |
最近更新发布: | 07/29/2019 |
实际学习开始日期: | 05/09/2019 |
预计主要完成日期: | 05/30/2019 |
预计完成日期: | 05/30/2019 |
状况或疾病
相
资格标准
有资格学习的性别 | All |
取样方式 | Non-Probability Sample |
接受健康志愿者 | 是 |
标准 | Inclusion Criteria: - Cancer patients who undertook a PET/CT examination independently of their disease status Exclusion Criteria: - Examinations prior to 2016 |
结果
主要结果指标
1. Assessment of thermogenic capacity of white adipocytes [The SUV of white adipocytes for each patient was measured once via the PET/CT software between 10-30 May 2019.]
2. Environmental temperature [The daily environmental temperature was obtained from Weather Underground (www.wunderground.com) on the 10th May 2019]