Genetics of Obesity in Chinese Youngs
关键词
抽象
描述
Obesity has become a major worldwide challenge to public health, owing to an interaction between the obesogenic environment and a strong genetic contribution.Previous studies found that genetic factors determine 40%-70% of obese phenotype.Under such circumstances, the screening of obesity susceptibility gene is particularly important for society or family to take measures to prevent obesity.
Recent extensive genome-wide association studies(GWASs) have identified numerous single nucleotide polymorphisms associated with obesity,but these loci together account for only a small fraction of the known heritable component.Two studies in 2010 Nature,for the first time, put rare copy number variation (CNV)in association with severe early-onset obesity.Their significance lie not only in the discovery of the pathogenic genes of severe early-onset obesity but,more importantly,in providing new strategies for finding out genes that cause complex diseases.
Obese patients and healthy lean controls proved by a series of blood biochemical examinations will be enrolled in this study.The present study intends to use the techniques such as enzyme-linked immunosorbent assay, real-time fluorescence quantitative PCR,gene chip,construction of viral vectors,transfection,taking advantage of the established database,by means of serum assays and functional tests, associate copy number variation with obesity phenotype to explain the root cause of obesity.Meanwhile biomarkers and genetic risk factors will be evaluated in the study subjects.
日期
最后验证: | 03/31/2016 |
首次提交: | 03/09/2010 |
提交的预估入学人数: | 03/09/2010 |
首次发布: | 03/10/2010 |
上次提交的更新: | 04/24/2016 |
最近更新发布: | 04/25/2016 |
实际学习开始日期: | 02/28/2009 |
预计主要完成日期: | 03/31/2021 |
预计完成日期: | 03/31/2021 |
状况或疾病
相
手臂组
臂 | 干预/治疗 |
---|---|
Healthy lean control group BMI:18.5-22.9kg/m2. Age:14-30 years old. To be proved normal by the examinations of liver and kidney function,blood lipids profile,fasting and postprandial plasma glucose, fasting insulin and HbA1c. | |
obesity group with BMI ≥30 obesity group 1500, lean healthy control group 1500 |
资格标准
有资格学习的年龄 | 14 Years 至 14 Years |
有资格学习的性别 | All |
取样方式 | Probability Sample |
接受健康志愿者 | 是 |
标准 | Inclusion Criteria: - body mass index (BMI)≥ 30kg/m2 - predominantly east China to minimize population stratification - willing and able to provide informed consent Exclusion Criteria: - pregnancy/lactation - Cushing syndrome - Hypothyroidism - obesity caused by pituitary and hypothalamic lesions - drug related obesity - history of major psychiatric illness |