Genotyping 2 SNPs in Chinese Breast Cancers
关键词
抽象
描述
Since the 1990s breast cancers incidence of china has increased more than twice as fast as global rates. Chinese patients are responsible for 12.2% of all newly diagnosed breast cancers and 9.6% of all deaths to world breast cancers. Breast cancer is now the second frequently diagnosed cancer and is the leading cause of cancer-related death in Chinese women.
Two of the most prevalent breast cancer susceptibility genes are BRCA1and BRCA2. However，because of population based Genetic heterogeneity, the frequency of BRCA1/BRCA2 mutation is not as high in Caucasian population as in China. Anyway, the mean age at diagnosis of breast cancer in China is almost 10 years younger and more cases are diagnosed before 40 than those in Caucasians. Therefore, it is believed that there are certain specific susceptibility loci in Chinese breast cancers.
In preliminary experiments, investigators found two germline mutations may associate with Chinese breast cancers.
The purpose of the study is to determine the frequency of two germline mutations by sanger-sequencing in a larger sample of Chinese breast cancers
日期
| 最后验证: | 08/31/2016 |
| 首次提交: | 08/28/2016 |
| 提交的预估入学人数: | 08/28/2016 |
| 首次发布: | 08/31/2016 |
| 上次提交的更新: | 09/12/2016 |
| 最近更新发布: | 09/14/2016 |
| 实际学习开始日期: | 07/31/2016 |
| 预计主要完成日期: | 05/31/2019 |
| 预计完成日期: | 05/31/2021 |
状况或疾病
干预/治疗
Genetic: rs183489969,rs185670819
相
手臂组
| 臂 | 干预/治疗 |
|---|---|
| Chinese Breast Cancers Woman with breast cancer that have been diagnosed in clinic | |
| healthy controls Woman without breast cancer |
资格标准
| 有资格学习的年龄 | 18 Years 至 18 Years |
| 有资格学习的性别 | Female |
| 取样方式 | Probability Sample |
| 接受健康志愿者 | 是 |
| 标准 | Inclusion Criteria: - Woman aged superior to 18 years old Inform consent signed Woman without breast cancer and family history of cancer Exclusion Criteria: - No inform consent signed Patient under guardianship, curatorship Psychosocial disorder |
结果
主要结果指标
1. Genotyping of 2 SNPs ( rs185670819 and rs183489969) in Chinese breast cancer patients and age-matched healthy control women . [January of 2019]
次要成果指标
1. Both of the 2 SNPs' minor allele frequency or affected ratio shows statistically significant differences between case and control groups [June of 2019]
