Green Tea Anticancer Mechanisms in Smokers
关键词
抽象
描述
Green tea contains phytochemicals, especially flavonoids. Phytochemicals are not absolutely required for normal functions, but may confer health benefits such as antioxidant actions. One can live without phytochemicals, but one may live longer and better with them. The phytochemicals in tea have been proposed to inhibit cancer onset via several different mechanisms. An obvious question is: Can anti-cancer actions of green tea be duplicated by black tea, which in the USA, is consumed more than green tea? The question remains unanswered, and will not be addressed by this project since many questions about green tea have not been answered yet. The contents of both type teas overlap in flavonoids, but green tea has more of the agents thought to be most effective. For example, some of the research cited below uses the flavonoid epigallocatechin gallate. Green tea has 5 times more of this flavonoid than black tea.
This study has two purposes. First, a case will be made that green tea may have several anti-cancer mechanisms, but this contention is not well confirmed by human intervention studies. This case will be made by addressing four questions. Second, justification will be given for the choice of mechanisms to be examined in this project's human intervention.
日期
| 最后验证: | 03/31/2015 |
| 首次提交: | 06/22/2010 |
| 提交的预估入学人数: | 07/12/2010 |
| 首次发布: | 07/13/2010 |
| 上次提交的更新: | 04/19/2015 |
| 最近更新发布: | 04/20/2015 |
| 实际学习开始日期: | 05/31/2010 |
| 预计主要完成日期: | 07/31/2013 |
| 预计完成日期: | 07/31/2013 |
状况或疾病
干预/治疗
Dietary Supplement: Green Tea
Other: No Green Tea
相
手臂组
| 臂 | 干预/治疗 |
|---|---|
| Experimental: Green Tea 4 cups daily of green tea for 6 weeks | Dietary Supplement: Green Tea Green Tea 4 cups daily |
| Placebo Comparator: No Green Tea 4 cups daily of placebo tea for 6 weeks | Other: No Green Tea 4 cups placebo tea for 6 weeks |
资格标准
| 有资格学习的年龄 | 23 Years 至 23 Years |
| 有资格学习的性别 | All |
| 接受健康志愿者 | 是 |
| 标准 | Inclusion Criteria: - Healthy 23-40 year old males and non-pregnant females, who are moderately heavy smokers (1-1.75 packs/day, > 2 years) Exclusion Criteria: - Habitual tea intake - Habitual flavonoid supplementation - Soy product intake over twice a week (soy is high in flavonoids). - Pulmonary diseases - Chronic or acute infection - Admission of heavy alcohol intake (> 14 beers or drinks a week) - Body mass index (BMI) > 30 (moderately overweight subjects will be taken) - Abnormal EKG - History of heart or other major health problems (ie arthritis, diabetes). - Subjects with slightly high blood pressure will be eligible for the project, but more severe hypertension (>150/100) |
结果
主要结果指标
1. Antioxidant effects of green tea versus placebo consumption. [Measured at post treatment]
次要成果指标
1. Non-antioxidant, cancer-relevant effects of green tea consumption [Measured at pre-treatment and post treatment]
