Losartan in Decompensated Heart Failure
关键词
抽象
描述
The inclusion criteria were hospitalization for decompensated heart failure defined by worsening of symptoms until fatigue or dyspnea at rest, low cardiac output defined by the clinical-hemodynamic profile, dobutamine dependence, and ejection fraction < 0.45, spontaneous breathing and receiving angiotensin-converting enzyme inhibitors. The patients could have jugular ingurgitation, lower limbs edema, ascites and rales. Dobutamine dependence was defined by infusion for more than 15 days or an unsuccessful attempt of withdrawal.
The exclusion criteria were serum creatinine > 3.0 mg/dL, serum potassium > 6.0 mEq/L, systolic blood pressure < 70 mm Hg, aortic stenosis, and acute coronary syndrome in the previous 2 months. The patients were randomly assigned by permuted block of 4, stratified by sex, to losartan or placebo.
The endpoints were change in B-type natriuretic peptide levels, cardiac index, pulmonary wedge capillary pressure, systemic vascular resistance, and successful withdrawal of dobutamine.
日期
最后验证: | 02/28/2011 |
首次提交: | 05/15/2013 |
提交的预估入学人数: | 05/16/2013 |
首次发布: | 05/19/2013 |
上次提交的更新: | 05/16/2013 |
最近更新发布: | 05/19/2013 |
实际学习开始日期: | 08/31/2008 |
预计主要完成日期: | 01/31/2011 |
预计完成日期: | 02/28/2011 |
状况或疾病
干预/治疗
Drug: Losartan
Drug: Placebo
相
手臂组
臂 | 干预/治疗 |
---|---|
Experimental: Losartan Losartan 50 mg bid orally | Drug: Losartan |
Placebo Comparator: Placebo Placebo 1 pill bid orally | Drug: Placebo |
资格标准
有资格学习的性别 | All |
接受健康志愿者 | 是 |
标准 | Inclusion Criteria: - hospitalization for decompensated heart failure - dobutamine dependence - ejection fraction < 0.45 - taking angiotensin-converting enzyme inhibitor Exclusion Criteria: - serum creatinine > 3.0 mg/dL - serum potassium > 6.0 mEq/L - systolic blood pressure < 70 mm Hg - aortic stenosis - acute coronary syndrome in the previous 2 months |
结果
主要结果指标
1. B-type natriuretic peptide [7 days]
次要成果指标
1. Successful withdrawal from dobutamine [7 days]
2. Worsening renal function [7 days]
3. Hyperkalemia [7 days]
4. Hypotension [7 days]