Melatonin Level and Postoperative Analgesia Consumption in Bariatric Surgery Patients.
关键词
抽象
描述
Bariatric surgical procedures are associated with low short-term mortality and may be associated with long-term reductions in all-cause, cardiovascular, and cancer-related mortality. This surgeries are major surgeries include risk of mortality still.
Melatonin is a hormone secreted from the pineal gland. Melatonin is an antioxidant, antinociceptive, hypnotic, anticonvulsant, neuroprotective, anxiolytic, sedative and analgesic. Irregularity of melatonin secretion causes a sleep irregularities, psychosis in intensive care unit and some behavioral disorder. The hypnotic, antinociceptive, and anticonvulsant properties of melatonin endow this neurohormone with the profile of a novel hypnotic-anesthetic agent.
The purpose of this study is to investigate the preoperative, perioperative and postoperative melatonin levels in bariatric surgery under general anesthesia and to investigate the relationship between melatonin level and analgesia requirement.
日期
| 最后验证: | 03/31/2017 |
| 首次提交: | 03/28/2017 |
| 提交的预估入学人数: | 04/03/2017 |
| 首次发布: | 04/10/2017 |
| 上次提交的更新: | 04/03/2017 |
| 最近更新发布: | 04/10/2017 |
| 实际学习开始日期: | 03/28/2017 |
| 预计主要完成日期: | 06/29/2017 |
| 预计完成日期: | 07/29/2017 |
状况或疾病
干预/治疗
Diagnostic Test: Melatonin and bariatric surgery
相
手臂组
| 臂 | 干预/治疗 |
|---|---|
| Melatonin and bariatric surgery the relationship between melatonin level and analgesia requirement. | Diagnostic Test: Melatonin and bariatric surgery the relationship between melatonin level and analgesia requirement. |
资格标准
| 有资格学习的年龄 | 18 Years 至 18 Years |
| 有资格学习的性别 | All |
| 取样方式 | Probability Sample |
| 接受健康志愿者 | 是 |
| 标准 | Inclusion Criteria: - American Society of Anesthesiologists (ASA) 3-4 status, aged between 18-65 years who are scheduled to undergo bariatric surgery. Exclusion Criteria: Patients with cardiovascular and pulmonary disease, those with ASA III-IV and propofol, fentanyl, remifentanil and rocuronium allergy. |
结果
主要结果指标
1. Melatonin Level [Change from Baseline melatonin at postoperative 24 hours]
次要成果指标
1. Morphine consumption [change from postoperative up to 24 hours]
