Neurobehavioral Effects of Partial Sleep Deprivation
关键词
抽象
日期
最后验证: | 03/31/2014 |
首次提交: | 04/09/2014 |
提交的预估入学人数: | 04/29/2014 |
首次发布: | 04/30/2014 |
上次提交的更新: | 06/08/2015 |
最近更新发布: | 06/10/2015 |
实际学习开始日期: | 11/30/2009 |
预计主要完成日期: | 03/31/2015 |
预计完成日期: | 03/31/2015 |
状况或疾病
干预/治疗
Behavioral: Sleep
相
手臂组
臂 | 干预/治疗 |
---|---|
No Intervention: Control 10 hours time-in-bed all nights of study | |
Experimental: 1 Recovery Night 2 baseline nights, five nights sleep restriction, 1 recovery night, five nights sleep restriction, 4 recovery nights | |
Experimental: 3 Recovery Nights 2 baseline nights, five nights sleep restriction, 3 recovery nights, five nights sleep restriction, 2 recovery nights | |
Experimental: 5 Recovery Nights 2 baseline nights, five nights sleep restriction, 5 recovery nights, five nights sleep restriction, 1 recovery nights |
资格标准
有资格学习的年龄 | 21 Years 至 21 Years |
有资格学习的性别 | All |
接受健康志愿者 | 是 |
标准 | Inclusion Criteria: A total of N=87 adult subjects (aged 21-50 yr), N=43 females and N=44 males of all ethnicities, will be randomized to the 3 different conditions (n=26 for each of 2 experimental conditions; n=11 for the control condition) for the 17-night protocol or assigned to the 5-night experimental recovery condition (n=24) for the 19-night protocol. Subjects must also be comparable in terms of their homeostatic and circadian sleep-wake regulation parameters. In order to be eligible to participate, subjects must meet the following inclusion criteria: 1. Age between 21 and 50 years (average age of our current protocols is 31 years) 2. Body mass index (BMI) within 20.5% of normal 3. Stable, normally-timed sleep-wake cycle as determined by interview, 2-week daily sleep log, and 2-week wrist actigraphic evidence, and defined by: 4. Habitual nocturnal sleep duration between 6.5h and 8.5h 5. Habitual morning awakening between 0600h and 0930h Exclusion Criteria: 1. No evidence of habitual napping 2. No shift work, transmeridian travel or irregular sleep/wake routine in the past 60 days 3. No sleep disorder, determined by history, actigraph, pulse oximetry and PSG 4. No history of mania or psychosis 5. No current depression as determined by the Beck Depression Inventory 6. No alcohol or drug abuse in the past year based upon history and urine toxicology screen 7. Not a current smoker 8. No acute, chronic, or debilitating medical conditions, major Axis I psychiatric illness, epilepsy, or thyroid disease, based on history, physical exam, blood and urine chemistries, and CBC |
结果
主要结果指标
1. Psychomotor Vigilance Test [Assessed everyday of the in-laboratory study (17 days) and is completed every 2 hours]