Oral β-Alanine Supplementation in Patients With COPD
关键词
抽象
日期
| 最后验证: | 01/31/2019 |
| 首次提交: | 05/08/2016 |
| 提交的预估入学人数: | 05/10/2016 |
| 首次发布: | 05/11/2016 |
| 上次提交的更新: | 02/20/2019 |
| 最近更新发布: | 02/21/2019 |
| 实际学习开始日期: | 04/30/2016 |
| 预计主要完成日期: | 01/31/2019 |
| 预计完成日期: | 01/31/2019 |
状况或疾病
干预/治疗
Dietary Supplement: COPD (beta-alanine)
Dietary Supplement: COPD (placebo)
Other: Healthy controls
相
手臂组
| 臂 | 干预/治疗 |
|---|---|
| Active Comparator: COPD (beta-alanine) | Dietary Supplement: COPD (beta-alanine) Patients receive beta-alanine |
| Placebo Comparator: COPD (placebo) | Dietary Supplement: COPD (placebo) Patients receive placebo |
| Other: Healthy controls | Other: Healthy controls Healthy controls will be assessed to compare baseline muscle carnosine levels |
资格标准
| 有资格学习的年龄 | 40 Years 至 40 Years |
| 有资格学习的性别 | All |
| 接受健康志愿者 | 是 |
| 标准 | Inclusion Criteria: - COPD: diagnosis of moderate to very severe COPD according to Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines - Healthy controls: forced expiratory volume at one second/forced vital capacity (FEV1/FVC) > 0.7, matched for age and gender Exclusion Criteria: - The presence of known instable cardiac disease - neurological disease and/or musculoskeletal disease that preclude safe participation in an exercise test - a history of drugs/alcohol abuse - vegetarianism - inability to understand the Flemish language. COPD-specific exclusion criteria: - COPD exacerbation and/or hospitalization in the last 6 weeks - participation in pulmonary rehabilitation in the previous 12 months. |
结果
主要结果指标
1. muscle carnosine [change from baseline to 12 weeks]
2. maximal exercise capacity [change from baseline to 12 weeks]
3. submaximal exercise capacity [change from baseline to 12 weeks]
次要成果指标
1. Functional exercise test 1 [change from baseline to 12 weeks]
2. Functional exercise test 2 [change from baseline to 12 weeks]
3. Muscle function quadriceps [change from baseline to 12 weeks]
4. Respiratory muscle function [change from baseline to 12 weeks]
5. Muscle function hand grip [change from baseline to 12 weeks]
6. Muscle characteristics [change from baseline to 12 weeks]
7. Blood parameters submaximal exercise test [change from baseline to 12 weeks]
8. Blood parameters fasted state [change from baseline to 12 weeks]
9. Blood parameters maximal exercise test [change from baseline to 12 weeks]
10. Comorbidities [change from baseline to 12 weeks]
11. Comorbidities: ankle-brachial pressure index [change from baseline to 12 weeks]
12. Comorbidities blood pressure [change from baseline to 12 weeks]
13. Comorbidities body composition 1 [change from baseline to 12 weeks]
14. Comorbidities body composition 2 [change from baseline to 12 weeks]
15. Quality of life: anxiety and depression [change from baseline to 12 weeks]
16. Quality of life: fatigue [change from baseline to 12 weeks]
17. Quality of life: dyspnea [change from baseline to 12 weeks]
18. Quality of life: general [change from baseline to 12 weeks]
19. Quality of life: COPD [change from baseline to 12 weeks]
20. Physical activity: accelerometer [change from baseline to 12 weeks]
21. Physical activity: questionnaire 1 [change from baseline to 12 weeks]
22. Physical activity: questionnaire 2 [change from baseline to 12 weeks]
23. Lung function [change from baseline to 12 weeks]
24. Heart function [change from baseline to 12 weeks]
