Pain in Adults With Autism Spectrum Disorder
关键词
抽象
描述
Adults with autism without intellectual disability (IQ > 85) are matched with members of siblings and control group (sex and chronological age).
Pain reactivity (Visual analog scale,endogenous modulation systems, salivary cortisol, automatic nervous system and behavioral responses to thermal stimulation assessed by an inspired behavior scale.) in adult with autism is tested using an experimental model of pain. Excitatory and inhibitory modulation systems were elicited using a temporal summation test administered before and after activation of the Diffuse Noxious Inhibitory Control (DNIC) by means of a cold-pressor test.
Demographic and clinical data are also collected (sensory profile, sleep disorders and depression inventory).
日期
| 最后验证: | 09/30/2017 |
| 首次提交: | 10/20/2014 |
| 提交的预估入学人数: | 10/26/2014 |
| 首次发布: | 10/28/2014 |
| 上次提交的更新: | 10/10/2017 |
| 最近更新发布: | 10/11/2017 |
| 实际学习开始日期: | 05/28/2015 |
| 预计主要完成日期: | 04/04/2017 |
| 预计完成日期: | 04/04/2017 |
状况或疾病
干预/治疗
Device: thermode
相
手臂组
| 臂 | 干预/治疗 |
|---|---|
| Experimental: high functioning Autism Thermal stimulation with test thermode Thermic stimulations (tonic heat pain stimulation and cold-pressor test) are used to test excitatory and inhibitory pain mechanisms with high functioning Autism | |
| Placebo Comparator: witness Thermic stimulations (tonic heat pain stimulation and cold-pressor test) are used to test excitatory and inhibitory pain mechanisms with a witness |
资格标准
| 有资格学习的年龄 | 18 Years 至 18 Years |
| 有资格学习的性别 | All |
| 接受健康志愿者 | 是 |
| 标准 | Non-specific inclusion criteria: - intellectual quotient >85 - consent form signed Inclusion Criteria autism group : - autism diagnosis (CIM 10) from multidisciplinary evaluation (ADI-r, ADOS) - sibling without autism or developmental disorder Non-specific Exclusion Criteria: - chronic pain - pregnancy, breast feeding - consent form no signed Exclusion criteria sibling and witness groups: - diagnosis of autism or developmental disorder |
结果
主要结果指标
1. Pain as assessed by Computerized Visual analog scale [one day]
次要成果指标
1. salivary cortisol [one day]
2. Behavioral response to thermal stimulation assessed by an inspired EDM-DI behavior scale [one day]
3. heart rate variability [one day]
