Pathophysiological Mechanisms of Fibromuscular Dysplasia
关键词
抽象
日期
最后验证: | 09/30/2016 |
首次提交: | 09/01/2013 |
提交的预估入学人数: | 09/01/2013 |
首次发布: | 09/04/2013 |
上次提交的更新: | 10/16/2016 |
最近更新发布: | 10/17/2016 |
实际学习开始日期: | 10/31/2011 |
预计主要完成日期: | 09/30/2014 |
预计完成日期: | 09/30/2014 |
状况或疾病
干预/治疗
Other: blood samples
Other: vascular echotracking
相
手臂组
臂 | 干预/治疗 |
---|---|
Other: Fibromuscular dysplasia Fibromuscular dysplasia:blood samples & vascular echotracking | |
Other: healthy volunteer healthy volunteer:blood samples & vascular echotracking | |
Other: hypertensive patients hypertensive patients:blood samples & vascular echotracking |
资格标准
有资格学习的年龄 | 18 Years 至 18 Years |
有资格学习的性别 | All |
接受健康志愿者 | 是 |
标准 | Inclusion Criteria for patients with multifocal fibromuscular dysplasia: - confirmed multifocal fibromuscular dysplasia - diagnosed for less than 10 years - without significant atherosclerotic disease or recent cardiovascular event - Statins and antiplatelet drugs are forbidden - hypertensive patients |
结果
主要结果指标
1. Comparison of circulating microparticles of patients vs. fibromuscular dysplasia with age and sex matched healthy volunteers and hypertensive patients [Once within 15 days]
次要成果指标
1. Comparison of circulating micro RNAs (miR-143 ; miR-145) between the 3 arms [Once within 15 days]
2. Comparison of matrixmetalloproteases between the 3 arms [Once within 15 days]
3. Comparison of c-reactive protein between the 3 arms [Once within 15 days]
4. Comparison of PLA2 between the 3 arms [Once within 15 days]
5. Comparison of endothelium dependant vasodilation between the 3 arms [Once within 15 days]
6. Comparison of endothelium independent vasodilation between the 3 arms [Once within 15 days]
7. Comparison of pulse wave velocity between the 3 arms [Once within 15 days]