Persistant Organics Pollutants in Breast Cancer.
关键词
抽象
描述
The investigators set up a longitudinal prospective monocentric cohort study in the gynecologic-oncologic surgery department of European Hospital Georges-Pompidou, with patients undergoing partial or total mastectomies, lymph node biopsies or axillary lymph node removal and sampling of the adipocytic tumour microenvironment to measure POPs using gas chromatography coupled to high-resolution mass spectrometry. The objective is to analyze the concentrations of 46 POPs including polychlorinated dibenzo(p)dioxins and furans (PCDD/Fs), polychlorinated biphenyls (PCBs), polybromodiphenyl ethers (PBDEs) and polybromobiphenyls (PBBs) in both adipose tissue (AT) and serum samples from breast tumor patients (benign, malignant with and without lymph node metastasis).
日期
| 最后验证: | 11/30/2018 |
| 首次提交: | 12/02/2018 |
| 提交的预估入学人数: | 12/25/2018 |
| 首次发布: | 12/26/2018 |
| 上次提交的更新: | 12/25/2018 |
| 最近更新发布: | 12/26/2018 |
| 实际学习开始日期: | 07/31/2013 |
| 预计主要完成日期: | 12/26/2013 |
| 预计完成日期: | 09/14/2017 |
状况或疾病
干预/治疗
Other: Blood test sample
Other: Peritumoral adipose tissue sample
相
资格标准
| 有资格学习的年龄 | 18 Years 至 18 Years |
| 有资格学习的性别 | All |
| 接受健康志愿者 | 是 |
| 标准 | Inclusion Criteria: - Patient with breast tumor: benign or malignant - Tumor size at least 1cm or palpable tumor - Undergoing a breast surgery in European Georges Pompidou hospital - Understanding the protocol and who signed a written consent Exclusion Criteria: patients unable to give informed consent - Dementia - Guardianship |
结果
主要结果指标
1. Metastatic lymph node status based of persistant organic pollutants level measured by by gas chromatography coupled to high-resolution mass spectrometry. [Sampling the day of surgery]
次要成果指标
1. Pro metastatic genes messenger ribonucleic acid (mARN) expression in the tumor based of metastatic lymph node status and persistant pollutants level. [2 years]
