Prediction and Pathogenesis of the Immune Reconstitution Inflammatory Syndrome
只有注册用户可以翻译文章
登陆注册
链接已保存到剪贴板
状态已完成
赞助商
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
合作者
University Hospital Tuebingen
Albert Schweitzer Hospital
临床试验: NCT01557803
BioSeek: NCT01557803
关键词
抽象
The objective of this project is to determine clinical and biological predictors of Immune Reconstitution Inflammatory Syndrome (IRIS) occurrence in HIV infected patients who are started on antiretroviral therapy (ART), and to obtain more insight into the pathogenesis of this syndrome. The investigators will prospectively study HIV infected patients in Sub Saharan Africa who will be initiated on ART and are at risk to develop IRIS in all its different appearances. In these patients, the investigators will assess the value of clinical features and plasma biomarkers to predict IRIS, and the investigators will obtain insight into which inflammatory pathways become activated during IRIS. This project will provide novel knowledge about this clinically highly relevant healthcare problem in a resource poor setting, namely in Lambaréné, Gabon, in the Central African rainforest belt. In Gabon little research has been done in the field of HIV. The epidemiological pattern of IRIS in Gabon will be described. Promising putative plasma biomarkers will be validated for their use in daily practice.
日期
最后验证: | 12/31/2014 |
首次提交: | 03/15/2012 |
提交的预估入学人数: | 03/18/2012 |
首次发布: | 03/19/2012 |
上次提交的更新: | 01/12/2015 |
最近更新发布: | 01/13/2015 |
实际学习开始日期: | 12/31/2011 |
预计主要完成日期: | 01/31/2014 |
预计完成日期: | 12/31/2014 |
状况或疾病
Immune Reconstitution Inflammatory Syndrome
Opportunistic Infections
相
-
手臂组
臂 | 干预/治疗 |
---|---|
Starting ART Adult patients starting anti retroviral therapy for the first time |
资格标准
有资格学习的年龄 | 18 Years 至 18 Years |
有资格学习的性别 | All |
取样方式 | Non-Probability Sample |
接受健康志愿者 | 是 |
标准 | Inclusion Criteria: - Age > 18 years - Informed consent - ART naive Exclusion Criteria: - No informed consent - History of ART use - Pregnancy |
结果
主要结果指标
1. IRIS [12 months]
Development of immune reconstitution inflammatory syndrome
次要成果指标
1. Time to IRIS [12 months]
Time to development of immune reconstitution inflammatory syndrome