Relation of Glucose and Acute Pancreatitis
关键词
抽象
描述
Acute pancreatitis (AP) is an acute inflammatory disease of the pancreas which can lead to a systemic inflammatory response syndrome with significant morbidity and mortality in 20% of patients. Part of endocrine function of pancreas would be affected in AP. Stress hyperglycemia would explode at acute phase. There are two reasons. One is because that sympathetic hyperactivity makes glucagon elevated. Secondary, microcirculation disorder makes pancreas edema, ischemia and necrosis, affecting secretion and excretion of insulin. In severe acute pancreatitis, there may be ketoacidosis. Many scoring systems for predicting prognosis of severe acute pancreatitis also contains glucose values, such as the Ranson scoring system and the Glascow scoring system. On the other hand, Type 2 diabetes has become a global pandemic disease. Most of patients of type 2 diabetes are obese, who easily complicated gallstone disease and hypertriglyceridemia. All of above could be the risk factors for acute pancreatitis. Our initial small sample research also suggests undiagnosed diabetes patients whose glucose value elevated is significantly worse than the known diabetic patients. Therefore, the investigators believe that glucose directly affects the prognosis of AP. So the investigators decide to follow up and observe 1000 cases of patients with acute pancreatitis, determining of blood sugar, blood amylase, hemoglobin and glycosylated hemoglobin level. At last, using ROC curve method to identify the die cutting between blood glucose level and acute pancreatitis, and makes analysis of the diagnostic value.
日期
最后验证: | 04/30/2014 |
首次提交: | 11/08/2011 |
提交的预估入学人数: | 11/09/2011 |
首次发布: | 11/10/2011 |
上次提交的更新: | 05/01/2014 |
最近更新发布: | 05/04/2014 |
实际学习开始日期: | 02/28/2011 |
预计主要完成日期: | 11/30/2011 |
预计完成日期: | 11/30/2011 |
状况或疾病
相
手臂组
臂 | 干预/治疗 |
---|---|
glucose value glucose value |
资格标准
有资格学习的年龄 | 15 Years 至 15 Years |
有资格学习的性别 | All |
取样方式 | Probability Sample |
接受健康志愿者 | 是 |
标准 | Inclusion Criteria: patients that newly diagnosed as acute pancreatitis. Exclusion Criteria: exclude other acute abdomen, such as peptic ulcer with perforation, mesenteric arterial embolism or ruptured ectopic pregnancy. |
结果
主要结果指标
1. motability [motability]