Safe Limits in Saturation (SLIM-study)
关键词
抽象
描述
This study consists of two parts a prospective and a retrospective part.
1. Prospective part: Patients in the ICU, the emergency room and the pulmonary function department of the VU university medical centre will be included. Arterial blood gas analysis is a tool often used to determine PaO2 in regular care. When an arterial blood gas analysis is performed for regular patient care, the corresponding SpO2 is measured. Information such as blood pressure, heart rate, amount of administered fluids and shock-related-parameters are obtained from the patient files. For the ICU patients capillary refill, acra temperature and the mottling scores are examined. The peripheral flow index and temperature index is measured. When more arterial blood gas samples are drawn over time in one patient, multiple datasets can be included per patient, as long as the samples are drawn two hours apart.
2. Retrospective part: Patients with a (suspected) pulmonary disease who underwent pulmonary function tests with arterial bloodgas sampling in the VU medical center and Medical Centre Alkmaar in the last 25 years. The PaO2 and corresponding SpO2 will be obtained from the test and parameters such as blood pressure, heart rate and administered oxygen will be retrieved from the databases with these test results.
日期
| 最后验证: | 09/30/2018 |
| 首次提交: | 11/29/2015 |
| 提交的预估入学人数: | 01/24/2016 |
| 首次发布: | 01/27/2016 |
| 上次提交的更新: | 10/15/2018 |
| 最近更新发布: | 10/17/2018 |
| 实际学习开始日期: | 11/30/2015 |
| 预计主要完成日期: | 07/31/2017 |
| 预计完成日期: | 07/31/2017 |
状况或疾病
相
手臂组
| 臂 | 干预/治疗 |
|---|---|
| ICU-patients (prospective) Critically ill patients (18 years and older) on mechanically ventilation who have an arterial line and require bloodgasanalysis for medical reasons | |
| Emergency Department (prospective) Patients (18 years and older), who are presented to the Emergency Department, and require bloodgasanalysis for medical reasons | |
| Pulmonary department (prospective) Patients (18 years and older) who visit the outpatient clinic of the pulmonary department for different pulmonary functional test and require bloodgasanalysis for medical reasons | |
| Pulmonary department (retrospective) Patients (18 years and older) who visited the outpatient clinic of the pulmonary department in the past of the VU medical centre in Amsterdam or the Medical Centre Alkmaar for different pulmonary functional test and required bloodgasanalysis for medical reasons |
资格标准
| 有资格学习的年龄 | 18 Years 至 18 Years |
| 有资格学习的性别 | All |
| 取样方式 | Probability Sample |
| 接受健康志愿者 | 是 |
| 标准 | Inclusion criteria for all inclusions: - Age: 18> - Requiring arterial bloodgas analysis Exclusion criteria for all inclusions: - Hyperbilirubinemia (>20 μmol/L) - CO-Hb (>1,5%) - MetHb (>1,5%) - Unreliable pulsatile SpO2 curve Additional inclusion criteria: - Prospective, ICU - VUmc: On mechanical ventilation. Arterial line in place. Additional exclusion criteria: - Prospective, ICU - VUmc: On extracorporeal membrane oxygenation. Therapeutic hypothermia. - Retrospective, Pulmonary function departments: Uncertainty whether SpO2 was measured exactly during arterial bloodgas sampling. |
结果
主要结果指标
1. Relation SpO2-PaO2 [Average of one week]
次要成果指标
1. Factors influencing PaO2-Spo2 relation [Average of one week]
2. Relation in SpO2-PaO2 in different populations [Average of one week]
3. Differences in relation in SpO2-PaO2 prospective versus retrospective [Average of one week]
