Serum and Urine Ghrelin in Adult Epileptic Patients
关键词
抽象
描述
Several neuropeptides have concerned with epilepsy pathogenesis, ghrelin showed an anticonvulsant effect. There is a potential relation between its level and antiepileptic drugs (AED) response. Objective: to evaluate ghrelin effect in adult epileptic patients and in response to AED. Methods: This case control study included 40 adult epileptic patients and 40 healthy controls. Participants were subjected to history taking of seizure semiology, full general and neurological examination, electroencephalography and cranial CT or MRI. Fasting serum acylated ghrelin (AG) and unacylated ghrelin (UAG) and urine AG levels were estimated to all participants by enzyme - linked immunosorbent assay (ELIZA).
日期
| 最后验证: | 03/31/2019 |
| 首次提交: | 04/17/2019 |
| 提交的预估入学人数: | 04/21/2019 |
| 首次发布: | 04/23/2019 |
| 上次提交的更新: | 04/21/2019 |
| 最近更新发布: | 04/23/2019 |
| 实际学习开始日期: | 05/31/2018 |
| 预计主要完成日期: | 01/29/2019 |
| 预计完成日期: | 02/04/2019 |
状况或疾病
相
手臂组
| 臂 | 干预/治疗 |
|---|---|
| group 1 Epileptic participants group consisted of 40 adults (15 females and 25 males) clinically and electrophysiological were diagnosed according to the international league against epilepsy classification 2010. | |
| group 2 Control group consisted of 40 adults (16 females and 24 males) non - epileptic healthy subjects. |
资格标准
| 有资格学习的年龄 | 18 Years 至 18 Years |
| 有资格学习的性别 | All |
| 取样方式 | Probability Sample |
| 接受健康志愿者 | 没有 |
| 标准 | Inclusion Criteria: - All participants were included if their age more than or equal to 18 years. Body mass index < 30 kg/m2, total cholesterol < 200mg/dl, serum triglycerides < 200 mg/dl and random blood glucose level < 126 mg/dl. Exclusion Criteria: - Participants had acute or chronic metabolic disorders (liver, kidney, thyroid, endocrine or gastrointestinal disorders). - Females with irregular menstrual cycle or on estrogen therapy (7). - Participants with organic cerebral lesion that was detected on cranial computed tomography (CT) or cranial magnetic resonance imaging (MRI). |
结果
主要结果指标
1. Serum ghrelin in Adult Epileptic Patients [6 months]
2. Urine ghrelin in Adult Epileptic Patients [6 months]
