Sucralose, Stevia, Gut Microbiome and Glucose Metabolism
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赞助商
University of Minnesota
临床试验: NCT02800707
BioSeek: NCT02800707
关键词
抽象
This study will determine the influence of two non-caloric sweeteners on glucose metabolism via the gut microbiome in adult men and women.
描述
This study will determine the influence of two non-caloric sweeteners on glucose metabolism via the gut microbiome in adult men and women aged 35-55 years.
日期
| 最后验证: | 02/28/2018 |
| 首次提交: | 06/09/2016 |
| 提交的预估入学人数: | 06/09/2016 |
| 首次发布: | 06/14/2016 |
| 上次提交的更新: | 03/20/2018 |
| 最近更新发布: | 03/21/2018 |
| 实际学习开始日期: | 01/02/2017 |
| 预计主要完成日期: | 01/30/2018 |
| 预计完成日期: | 01/30/2018 |
状况或疾病
Impaired Glucose Tolerance
干预/治疗
Other: Sucralose
Other: Stevia
相
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手臂组
| 臂 | 干预/治疗 |
|---|---|
| Active Comparator: Sucralose Participants will be asked to consume 180 mg/day of sucralose (in the form of capsules which is equivalent to three 12-oz cans of diet soda) for 14 days. According to the FDA, a 150 lb. person may consume up to 340 mg/day of sucralose (or 5.5 12-oz cans of sucralose-sweetened diet soda). | Other: Sucralose Sweetner |
| Active Comparator: Stevia Participants will be asked to consume 180 mg/day of stevia (in the form of capsules which is equivalent to three 12-oz cans of diet soda) for 14 days. According to the FDA, a 150 lb. person may consume up to 800 mg/day of stevia (or about 12 cans of stevia-sweetened diet soda). | Other: Stevia Sweetner |
资格标准
| 有资格学习的年龄 | 35 Years 至 35 Years |
| 有资格学习的性别 | All |
| 接受健康志愿者 | 是 |
| 标准 | Inclusion Criteria: Generally health adult men and women aged 35-55 years old - Exclusion Criteria:Adults will not be eligible who have chronic disease (cancer, CHD, diabetes, chronic kidney disease); pregnant or breast feeding; menopausal; has a history of bariatric surgery; taking prednisone/steroids, taking medication for PCOS, or take medications that influence blood glucose. - |
结果
主要结果指标
1. 2-hour glucose [14 days]
An oral glucose tolerance test will be administered before and after consuming assigned sweetener to determine change in 2-hour glucose
次要成果指标
1. Gut microbiome [14 days]
Gut microbiota will be measured before and after consuming assigned sweetener to determine change in gut microbiota.
