Support for the Rhabdomyolysis in an Emergency Department

只有注册用户可以翻译文章

登陆注册

链接已保存到剪贴板

状态

赞助商

Groupe Hospitalier Paris Saint Joseph

临床试验: NCT02896517

BioSeek: NCT02896517

关键词

抽象

Rhabdomyolysis is a common condition in the UAA. Support is heterogeneous, it is in most cases a mass hyperhydration. The idea is to initially with an EPP simultaneously screened for the most affected by this disease and aggravating factors population, associated comorbidities.

The rhabdomyolysis prognosis depends mainly on the etiology and associated comorbidities.

- Acute renal failure and hyperkalemia are the major complications that worsen the prognosis.

- In most cases, acute renal failure is reversible. Acute renal failure caused by renal vasoconstriction with ischemia, precipitation of myoglobin in the tubules and direct cytotoxic action of myoglobin.

If the prime mover of rhabdomyolysis is ischemia (or hypoxia) cell, we now know that the tissue damage is greatly aggravated during muscle reperfusion, creating ischemia-reperfusion. Reperfusion will not only cause the release into the bloodstream of the cell contents myocytes but also an increase in necrotic areas. Indeed, the massive arrival of oxygen at the myocyte will cause significant production of free radicals, increasing their toxic effects.

Predictive factors of acute renal failure is creatinine and urea. The urine alkalinisation by bicarbonates is questionable oral alkalizing seems to be an alternative when possible (oral alkaline solution) but not used to this day.

The track N-acetyl cysteine as an antioxidant that can possibly have an effect on release of the free radicals during reperfusion by decreasing their toxicity is still not considered clinically.

描述

Main objective / secondary:

Evaluation of current professional practice:

I. Identify the most common etiologies encountered in our SAU. II. Identify the / types of people most affected by this disease III. Detect the most common complications of H0 support and evolution H48 if the patient not transferred IV. Evaluate the emergency treatment at the initial charge.

Methodology :

DESIGN:

It is a non-interventional retrospective single-center study, within the Department of Emergency GHPSJ, to an EPP and output the results regarding the type of population most affected by this disease with the most common etiologies in our support (what we are doing).

Time study:

Study on patient records being passed on to the emergency 12 months out with a diagnosis of rhabdomyolysis.

日期

最后验证:	07/31/2018
首次提交:	08/30/2016
提交的预估入学人数:	09/05/2016
首次发布:	09/11/2016
上次提交的更新:	08/08/2018
最近更新发布:	08/12/2018
实际学习开始日期:	09/30/2016
预计主要完成日期:	09/30/2016
预计完成日期:	09/30/2016

状况或疾病

Rhabdomyolysis

相

资格标准

有资格学习的性别	All
取样方式	Non-Probability Sample
接受健康志愿者	是
标准	Inclusion Criteria: - All adults with CPK greater than 5N or 500 IU / L in sera to emergencies Exclusion Criteria: - No exclusion criteria

结果

主要结果指标

1. Assessment of change of patient complication by answering a questionary [Hour 0, Hour 48]

Detect the most common complications of Hour 0 support and evolution Hour 48 if the patient not transferred. Hour 0 support and evolution at Hour 48

Support for the Rhabdomyolysis in an Emergency Department

关键词

urea

hypoxia

ischemia

rhabdomyolysis

hyperkalemia

creatinine

cysteine

抗氧化剂

抽象

描述

日期

状况或疾病

相

资格标准

结果

科学支持的最完整的草药数据库