The Association Between Areca-nut Chewing Habit and Metabolic Syndrome
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Taichung Veterans General Hospital
临床试验: NCT02175524
BioSeek: NCT02175524
关键词
抽象
The purpose of this study is going to determine the odds ratio of metabolic syndrome (MS), the habit of areca nut chewing, antioxidant, and inflammatory status in oral and esophageal patients. The current study was designed as a case-control study. Patients proved to be oral and esophageal cancer and had the habit of areca nut chewing are defined as case group. Patients proved to be oral and esophageal cancer and did not have the habit of areca nut chewing are defined as control group. The participants' age, blood pressures, and smoking habits will be recorded. Body weight, height, waist, and hip circumferences will be measured. Fasting venous blood samples will be obtained to determine hematological parameters [i.e., serum creatinine, total cholesterol, triacylglycerol, low density lipoprotein-cholesterol, high density lipoprotein-cholesterol, malondialdehyde, superoxide dismutase, glutathione peroxidase, catalase, and inflammatory markers (C-reactive protein, tumor necrosis factor-alpha, and interleukin-6)]. Logistic regression analyses are going to perform to examine the relationship between areca nut chewing and MS in this population. If we can make sure the relationship between areca nut chewing and MS, the clinicians and nutritionists can teach people to quit areca nut chewing in order to avoid the possibility of developing metabolic syndrome and cardiovascular disease.
日期
最后验证: | 05/31/2014 |
首次提交: | 06/23/2014 |
提交的预估入学人数: | 06/23/2014 |
首次发布: | 06/25/2014 |
上次提交的更新: | 06/23/2014 |
最近更新发布: | 06/25/2014 |
实际学习开始日期: | 03/31/2014 |
预计主要完成日期: | 11/30/2017 |
状况或疾病
Oral and Esophageal Cancer
Metabolic Syndrome.
相
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手臂组
臂 | 干预/治疗 |
---|---|
Case Patients proved to be oral and esophageal cancer and had the habit of areca nut chewing. | |
Control Patients proved to be oral and esophageal cancer and did not have the habit of areca nut chewing. |
资格标准
有资格学习的年龄 | 20 Years 至 20 Years |
有资格学习的性别 | All |
取样方式 | Non-Probability Sample |
接受健康志愿者 | 是 |
标准 | Inclusion Criteria: - Patients proved to be oral and esophageal cancer will be recruited. Exclusion Criteria: - Subjects with diabetes mellitus, liver, renal diseases, or undergoing statin therapy. - Taking antioxidant vitamins supplements. |
结果
主要结果指标
1. Metabolic syndrome [Up to 1 week]
Measure blood pressure, blood lipid profiles, fasting glucose, and waist circumferences.
次要成果指标
1. Antioxidant activity [Up to 1 week]
Antioxidant ability measurements: lipid peroxidation markers (MDA), antioxidant enzymes activities (catalase, glutathione peroxidase, and superoxide dismutase).
2. Inflammatory status [Up to 1 week]
Measure inflammatory markers: C-reactive protein, Interleukin-6, and tumor necrosis factor-alpha.