The Chinese Early-onset Hypertension Study (CHESS)
关键词
抽象
描述
In this study, the hypertensive individuals are consecutively recruited from multiple centers, with an early onset age (less than 40 when diagnosed). A complete clinical history (information on history of hypertension, demographic characteristics, personal and family medical history) are collected by a trained staff using a standardized questionnaire on the first day of baseline observation, and physical examination are also collected in a standard procedure. Blood samples are collected after 12-hour overnight fast and biological variables are determined. Genomic DNA is isolated from leukocytes according to a standard procedure. The individuals will receive follow-up in an ordinal system. The investigators will focus on the clinical and genetic features, genotype-phenotype correlations and influencing factors of prognosis in Chinese early-onset hypertension patients.
日期
| 最后验证: | 12/31/2017 |
| 首次提交: | 05/19/2016 |
| 提交的预估入学人数: | 06/28/2016 |
| 首次发布: | 06/29/2016 |
| 上次提交的更新: | 01/06/2018 |
| 最近更新发布: | 01/08/2018 |
| 实际学习开始日期: | 09/30/2012 |
| 预计主要完成日期: | 11/30/2020 |
| 预计完成日期: | 11/30/2020 |
状况或疾病
相
手臂组
| 臂 | 干预/治疗 |
|---|---|
| early-onset hypertension early-onset hypertension patients recruited in Chinese multiple centers |
资格标准
| 有资格学习的性别 | All |
| 取样方式 | Non-Probability Sample |
| 接受健康志愿者 | 是 |
| 标准 | Inclusion Criteria: - In accordance with the diagnosis of hypertension (BP≥140/90mmHg), and less than 40 years when diagnosed Exclusion Criteria: - |
结果
主要结果指标
1. primary mortality of early-onset hypertension [through study completion, an average of 5 years]
次要成果指标
1. secondary outcomes of heart [through study completion, an average of 5 years]
2. secondary outcomes of brain [through study completion, an average of 5 years]
3. secondary outcomes of kidney [through study completion, an average of 5 years]
4. secondary outcomes of eyes [through study completion, an average of 5 years]
