Treatment of Depression in Parkinson's Disease
关键词
抽象
描述
Depression as the most common non-motor comorbidity of Parkinson's disease (PD), have a negative impact on disability and quality of life.
Traditional Chinese Medicine has shown effects on several depression. It is not known if TCM also is effective for depression in PD. This study is to investigate "Xiaoyao Pill", an antidepressant in TCM, on depression in PD.
A total of 60 patients with depression in PD will be randomized to each of the three arms.
日期
| 最后验证: | 07/31/2011 |
| 首次提交: | 08/10/2011 |
| 提交的预估入学人数: | 08/10/2011 |
| 首次发布: | 08/14/2011 |
| 上次提交的更新: | 08/10/2011 |
| 最近更新发布: | 08/14/2011 |
| 实际学习开始日期: | 04/30/2008 |
| 预计主要完成日期: | 09/30/2011 |
| 预计完成日期: | 11/30/2011 |
状况或疾病
干预/治疗
Drug: group 1
Drug: group 2
Drug: group 3
相
手臂组
| 臂 | 干预/治疗 |
|---|---|
| Experimental: group 1 | Drug: group 1 herb extracts,were received two times a day for 12 weeks without dose changing. |
| Active Comparator: group 2 | Drug: group 2 herb extracts, were received two times a day for 12 weeks without dose changing. |
| Placebo Comparator: group 3 | Drug: group 3 The placebo looked like herb extracts and were also received two times a day for 12 weeks without dose changing. |
资格标准
| 有资格学习的年龄 | 30 Years 至 30 Years |
| 有资格学习的性别 | All |
| 接受健康志愿者 | 是 |
| 标准 | Inclusion Criteria: - Parkinson's disease without dementia - Depression - Males or females - Willing and able to give informed consent Exclusion Criteria: - cognitive dysfunction - other serious diseases |
结果
主要结果指标
1. Hamilton Depression Scale [12 weeks]
次要成果指标
1. the responder rate (defined as score reduction of HAMD-17>=50%) [12 weeks]
2. the Geriatric Depression Scale [12 weeks]
