Whole Grain and Fiber Addition Study
关键词
抽象
日期
| 最后验证: | 09/30/2019 |
| 首次提交: | 04/11/2018 |
| 提交的预估入学人数: | 08/06/2018 |
| 首次发布: | 08/08/2018 |
| 上次提交的更新: | 10/29/2019 |
| 最近更新发布: | 10/31/2019 |
| 实际学习开始日期: | 05/03/2018 |
| 预计主要完成日期: | 02/28/2019 |
| 预计完成日期: | 02/28/2019 |
状况或疾病
干预/治疗
Other: Fiber cereal
相
手臂组
| 臂 | 干预/治疗 |
|---|---|
| Experimental: Fiber Intervention I Participants will be asked to consume two ½ cup servings of fiber cereal daily (equivalent to 28 g fiber) for 14 days, one in the morning and one in the evening. | |
| Experimental: Fiber Intervention II Participants will be asked to consume two ¼ cup servings of fiber cereal daily (equivalent to 14 g fiber) for 14 days, one in the morning and one in the evening. |
资格标准
| 有资格学习的年龄 | 18 Years 至 18 Years |
| 有资格学习的性别 | All |
| 接受健康志愿者 | 是 |
| 标准 | Inclusion Criteria: - Healthy adults over 18 years - BMI between 18 and 30 - English speaker with ability to use a computer/smartphone. Exclusion Criteria: - Women who are currently pregnant or breastfeeding - Current use of antibiotics or use of antibiotics within the last month - Self-reported, pre-existing history of gastrointestinal disease including IBD, IBS, Crohn's disease, Celiac disease (or self-reported sensitivity to gluten), history of bowel blockage/impacted stool, fecal incontinence, gastroparesis or diverticulosis. - Type I/II diabetes mellitus - Participants actively trying to lose weight - Chronic use of antacids and/or laxatives - Use of seizure disorder medications or tricyclic antidepressants - Consumption of drugs or supplements related to energy intake (i.e. diet pills and appetite suppressants) |
结果
主要结果指标
1. Change in microbiome stability [Change from baseline to 6 weeks]
次要成果指标
1. Microbiome functional capacity [Baseline, 2 weeks, 6 weeks]
2. Urinary metabolome [Baseline, 2 weeks, 6 weeks]
3. Fecal short chain fatty acids [Baseline, 2 weeks, 6 weeks]
