A Diagnostic Test for Familial Mediterranean Fever
关键词
抽象
日期
| 最后验证: | 10/31/2018 |
| 首次提交: | 11/13/2018 |
| 提交的预估入学人数: | 11/18/2018 |
| 首次发布: | 11/19/2018 |
| 上次提交的更新: | 11/18/2018 |
| 最近更新发布: | 11/19/2018 |
| 实际学习开始日期: | 12/31/2018 |
| 预计主要完成日期: | 06/30/2020 |
| 预计完成日期: | 06/30/2020 |
状况或疾病
干预/治疗
Other: In vitro functional test
Other: Healthy donors
相
手臂组
| 臂 | 干预/治疗 |
|---|---|
| Familial Mediterranean Fever (patients) Patients with previously confirmed Familial Mediterranean Fever (based on clinical criteria) | |
| Control group (patients) Patients with symptoms similar to that of Familial Mediterranean Fever (e.g. Behcet disease, Crohn, sepsis..) but without confirmed Familial Mediterranean Fever. | |
| Healthy donors Patients without symptoms (anonymous blood donors) | Other: Healthy donors Measurement of interleukin-1beta secretion by monocytes and measurement of cell death upon Pyrin inflammasome activation by kinase inhibitor on samples from healthy subjects who donated their blood to the French Blood Establishment. |
资格标准
| 有资格学习的年龄 | 4 Years 至 4 Years |
| 有资格学习的性别 | All |
| 取样方式 | Probability Sample |
| 接受健康志愿者 | 是 |
| 标准 | Inclusion Criteria: - Clinical picture compatible with an Familial Mediterranean Fever and an earlier genetic analysis finding a mutation of the MEFV gene; - Newly diagnosed or undergoing follow-up (without criteria of delay or evolutionary stage); - In the course of specific or non-specific treatment of the disease or without treatment; - For whom a blood test is planned as part of the routine care; - Of whom the informed non-opposition has been collected (parental authorization in the case of a minor patient); Exclusion Criteria: - patient under legal protection or under safeguard of justice or any other measures of protection (guardianship, curatorship); - Person unable to express his consent; - Person in emergency situation, vital or not; - Infection known to HIV and / or HBV and / or HCV |
结果
主要结果指标
1. Differences in interleukin-1bβ levels [Less than 48 hours]
