Analgesic Effects of Gabapentin and Paracetamol
关键词
抽象
描述
Gabapentin is an anti-convulsion medication and has a high affinity for voltage-gated calcium channel throughout the brain, acts by inhibition of release of excitatory neurotransmitters. As a lipophilic substance, it shows linear pharmacokinetics and has oral bioavailability greater than 90%. Gabapentin is used in a variety of condition as a therapeutic measure involving diabetic neuropathy, post-herpetic neuralgia, in partial seizures, restless leg syndrome, post-menopausal hot flashes, anxiety, resistant mood disorders, essential tremors, and numerous other modalities. Gabapentin is a muscle relaxant and anti-spasmodic, its analgesic effect has also be identified for moderate to severe pain.
日期
| 最后验证: | 12/31/2019 |
| 首次提交: | 11/10/2018 |
| 提交的预估入学人数: | 08/22/2019 |
| 首次发布: | 08/27/2019 |
| 上次提交的更新: | 01/21/2020 |
| 最近更新发布: | 01/26/2020 |
| 实际学习开始日期: | 08/31/2019 |
| 预计主要完成日期: | 01/06/2020 |
| 预计完成日期: | 01/20/2020 |
状况或疾病
干预/治疗
Drug: Gabapentin 600 mg Tab
相
手臂组
| 臂 | 干预/治疗 |
|---|---|
| Experimental: Group A Gabapentin 600 mg Tab | |
| Active Comparator: Group B Paracetamol 1000 mg Tab |
资格标准
| 有资格学习的年龄 | 18 Years 至 18 Years |
| 有资格学习的性别 | All |
| 接受健康志愿者 | 是 |
| 标准 | 1. Inclusion Criteria: 1. Patients between 18-60 years of age 2. Patients Undergoing hand surgery in the Department of Plastics and Reconstructive Surgery, Dr. Ruth KM Pfau Civil Hospital Karachi, Dow University of Health Sciences 2. Exclusion criteria: 1. Pregnant women 2. Any patient presenting with the signs of: - Arrhythmia - Myocardial ischemia - Cognitive impairment - Psychiatric disorders - Drug abuse 3. Patients sensitive to any epileptic drug or taking any anti-epileptic drug 4. Having severe and multiple injuries. |
结果
主要结果指标
1. Comparison of analgesic effects of Gabapentin and paracetamol in patients with hand injury [6 months]
