Antidepressant Monotherapy on Depressive and Anxiety Symptom in Chinese Patients

Inclusion Criteria:

1. First episode outpatients in department of psychiatry, aged 18-65 years

2. Comorbidity of MDD and GAD according to DSM-5 criteria Hamilton Depression score (HAMD) of ≥18 at screening

3. HAMA≥14 at screening

4. Medically stable

5. Provision of written, informed consent.

Exclusion Criteria:

1. Suicide ideation

2. Use antidepressants within at least 14 days before study begin

3. Substance or alcohol dependence at enrolment (except dependence in full remission, and except for caffeine or nicotine dependence)

4. Opiates, amphetamine, barbiturate, cocaine, cannabis, or hallucinogen abuse within 4 weeks prior to enrolment

5. Unstable or inadequately treated medical illness (e.g. congestive heart failure, angina pectoris, hypertension, renal or hepatic dysfunction, cerebrovascular disease ) as judged by the investigator

6. Women in pregnancy or lactation

7. Medical conditions that would affect absorption, distribution, metabolism or excretion of study treatment.

8. Medical history with seizure disorder, except for febrile convulsion

9. Participation in another clinical study within 4 weeks (or longer time according to the local requirement)

10. Receive Electroconvulsive therapy (ECT) before study begin