Antioxidants in Gestational Diabetes
关键词
抽象
描述
The 200 pregnant women with Gestational diabetes mellitus were randomized using automated web based randomization system into 2 groups, Group1 received 1 gram L-ascorbic acid oral once daily (vitamin C )per day from the time of diagnosis until the time of delivery in addition to routine treatment of diabetes (diet & insulin). Group2 received only the treatment of diabetes (diet and insulin
日期
| 最后验证: | 02/28/2017 |
| 首次提交: | 01/25/2015 |
| 提交的预估入学人数: | 02/02/2015 |
| 首次发布: | 02/03/2015 |
| 上次提交的更新: | 03/21/2017 |
| 最近更新发布: | 03/23/2017 |
| 实际学习开始日期: | 12/31/2012 |
| 预计主要完成日期: | 01/31/2015 |
| 预计完成日期: | 01/31/2015 |
状况或疾病
干预/治疗
Drug: antioxidant
相
手臂组
| 臂 | 干预/治疗 |
|---|---|
| Active Comparator: antioxidant 1 gram L-ascorbic acid (vitamin C capsule) orally once per day from the time of diagnosis until the time of delivery in addition to treatment for gestational diabetes mellitus in the form of diet and insulin | Drug: antioxidant 1 gram L-ascorbic acid (vitamin C …..) per day from the time of diagnosis until the time of delivery |
| No Intervention: control Only treatment for gestational diabetes mellitus in the form of diet and insulin |
资格标准
| 有资格学习的年龄 | 20 Years 至 20 Years |
| 有资格学习的性别 | Female |
| 接受健康志愿者 | 是 |
| 标准 | Inclusion Criteria: - Women with the diagnosis of GDM Exclusion Criteria: - Women with multiple pregnancies - Chronic medical disorders e.g. anemia - Hypertension - Liver disease or renal disease - Those with obstetric problems other than GDM (e.g. pre-eclampsia & antepartum hemorrhage) or smokers and women with preexisting type I or II diabetes mellitus were excluded from our study |
结果
主要结果指标
1. neonatal outcome assessed by neonatal ICU admission [1 week after delivery]
次要成果指标
1. oxidative stress parameters: non enzymatic and enzymatic oxidative stress parameters in placental tissue homogenates in women with GDM named glutathione ,malondialdahyde,superoxide dismutase ,catalase and glutathione peroxidase [9 months of pregnancy]
2. oxidative stress parameters: non enzymatic and enzymatic oxidative stress parameters in maternal blood plasma/lysate in women with GDM named glutathione,superoxide dismutase ,catalase and glutathione peroxidase [9 months of pregnancy]
3. oxidative stress parameters: non enzymatic and enzymatic oxidative stress parameters in neonatal blood in women with GDM named malondialdahyde and superoxide dismutase [9 months of pregnancy]
