Antiseptic and Analgesic Action Acmella Oleracea Skin: Randomized Clinical Trial
关键词
抽象
描述
Context: Research on natural products with therapeutic, analgesic or antimicrobial purpose should be encouraged to create new drugs. Acmella oleracea, typical plant of the Northern region of the country and popularly known as jambu, has aroused the interest of researchers because of its therapeutic potential. Objective: To evaluate the potential topical analgesic and antimicrobial of Acmella oleracea plant extract from the skin antisepsis in venipuncture procedures. Methods: This is a clinical, randomized, controlled trial with healthy volunteers recruited at the Clinic I of the collection of biological materials sector of the Hospital das Clinicas Samuel Libânio, in Pouso Alegre-MG. The plant extract A. oleracea manipulated with Transcutol® and 70% alcohol were used in the volunteers before the venipuncture procedure as allocation in study groups. Held collection of skin microbiota by the swab technique and the end of the venipuncture procedure was applied to the volunteer, the visual numeric scale (VNS) standard to determine the degree of pain.
日期
| 最后验证: | 05/31/2016 |
| 首次提交: | 05/22/2016 |
| 提交的预估入学人数: | 06/06/2016 |
| 首次发布: | 06/07/2016 |
| 上次提交的更新: | 06/06/2016 |
| 最近更新发布: | 06/07/2016 |
| 实际学习开始日期: | 08/31/2015 |
| 预计主要完成日期: | 08/31/2015 |
| 预计完成日期: | 08/31/2015 |
状况或疾病
干预/治疗
Other: Acmella oleracea
Other: alcohol 70%
相
手臂组
| 臂 | 干预/治疗 |
|---|---|
| Active Comparator: Acmella oleracea The plant extract A. oleracea manipulated with Transcutol® were used in the volunteers 3 minutes before the venipuncture | Other: Acmella oleracea The plant extract A. oleracea manipulated with Transcutol® were used in the volunteers before the venipuncture procedure as allocation in study groups. Held collection of skin microbiota by the swab technique and the end of the venipuncture procedure was applied to the volunteer, the visual numeric scale (VNS) standard to determine the degree of pain. |
| Placebo Comparator: alcohol 70% 70% alcohol were used in the volunteers 3 minutes before the venipuncture | Other: alcohol 70% 70% alcohol were used in the volunteers before the venipuncture procedure as allocation in study groups. Held collection of skin microbiota by the swab technique and the end of the venipuncture procedure was applied to the volunteer, the visual numeric scale (VNS) standard to determine the degree of pain. |
资格标准
| 有资格学习的年龄 | 18 Years 至 18 Years |
| 有资格学习的性别 | All |
| 接受健康志愿者 | 是 |
| 标准 | Inclusion Criteria: - healthy volunteers - without restriction as to ethnicity - educational level and social class who agreed to participate by signing the Informed Consent and Informed (IC ) Exclusion Criteria: - pregnant women (due to contractile properties that can cause ) - cancer patients - chronic and refusal to participate in the study kidney |
结果
主要结果指标
1. The degree of pain in 15 healthy volunteers will be measured by the visual numeric scale (VNS) standard immediately after the venipuncture procedure. [1 day]
2. The skin microflora in 15 healthy volunteers will be measured counted the microorganism isolated by swab technique and plated on plates containing the medium Standard Methods Agar (PCA). [1 day]
