Applying PET/MR for Dementia Applications
关键词
抽象
描述
Simultaneous measurements of PET and MR together as is recently became possible have allow spatial and temporal correlation between the two modalities opening a window of opportunities that was not available so far. The first practical advantage is because most neurological patients should go through both MRI and PET scans. Allowing both scans in the occasion significantly increase patient comfort. Furthermore, the simultaneous scans in contrast to sequential scans allow correlation between PET and MR informaiton without the concern of pathological brain modifications between the scans. Currently PET is performed combined with CT, which is superior to MR in the field of brain images. MR high soft tissue resolution as well as extra information it may provide regarding brain perfusion, diffusion, metabolic parameters etc., make the MR a far better modality for brain imaging than CT. In addition, the combined tool allow leveraging MR data to improve PET data quantification. PET issues such as motion correction, partial volume effect and correct localization of the tracer in the brain anatomy that cause PET image degradation and lower accuracy and robustness of PET quantitative parameters, can be solved by integrating MR data into the analysis. Several recently published articles have demonstrated different correction approaches for motion correction and partial volume effect showing an improvement in the PET images both visually and quantitatively . PET attenuation correction using MR data have also been studied, however this matter still need to be resolved. PET/MR for neurological conditions, in general, and specifically for conditions resulting in dementia, is a promising application with a large variety of research opportunities and its abilities need to be explored. Optimization of the acquisition protocols and even more so, the analysis and quantification protocols still need to be performed and will be the focus of this study.
日期
最后验证: | 10/31/2019 |
首次提交: | 10/28/2019 |
提交的预估入学人数: | 11/03/2019 |
首次发布: | 11/05/2019 |
上次提交的更新: | 11/03/2019 |
最近更新发布: | 11/05/2019 |
实际学习开始日期: | 01/09/2020 |
预计主要完成日期: | 03/09/2021 |
预计完成日期: | 01/09/2022 |
状况或疾病
干预/治疗
Diagnostic Test: Dementia Patients
相
手臂组
臂 | 干预/治疗 |
---|---|
Experimental: Dementia Patients | Diagnostic Test: Dementia Patients The PET will be performed with one of the following tracers: 18F-FDG, 18F-DOPA or 18F-flutemetamol (Vizamyl). Proper tracer will be determined by the physician according to the condition. Patients that will agree, will be asked to perform two scans each with different tracer. The 3 tesla magnet of the MRI should allow acquisition of several contrasts within a reasonable time frame. The protocol will include T1 and T2-weighted images, perfusion and diffusion images. Images will be analyzed visually and quantitatively. Quantitative analysis will include MR parameters such as DWI apparent diffusion coefficient (ADC) and PET quantitative metabolic data such as standard uptake values (SUV), metabolic tumor volume (MTV), and total lesion glycolysis (TLG). Hidden image parameters will also be extracted for texture analysis purposes. Quantitative data will be correlated to clinical and pathological data to check accuracy, specificity and sensitivity. |
资格标准
有资格学习的年龄 | 18 Years 至 18 Years |
有资格学习的性别 | All |
接受健康志愿者 | 是 |
标准 | Inclusion Criteria: patients over the age of 18 with diagnosed conditions that might result in dementia or with diagnosed dementia in different stages. Exclusion Criteria: 1. Patients younger than 18 years 2. pregnancy 3. contraindication to MRI or to intravenous gadolinium injection. |
结果
主要结果指标
1. Patients who preformed PET/MR for dementia applications [1 year]