Avenanthramide and Saponin Bioavailability in Oat Bran
关键词
抽象
描述
Initially, the diet of the participants will be asked to restricted to avoid eating any polyphenols that might interfere with the employed analytical chemistry techniques. This period of diet restriction is the washout period. The list of foods to avoid are: oats, whole grains, fruits, vegetables, herbal supplements, ginger, coffee, tea, and chocolate.
After the washout period, a baseline urine and fecal sample will be collected from the participants, then a large portion of oat bran will be provided to the participants for consumption. The approximate portion size will be 100 g by dry weight. The participants will then provide urine samples during the designated time points. The time points for the urine collection are as follows:
1. st sample, ~ 30 min to 1 hour prior to oat consumption
2. nd sample: 0-2 hours after oat consumption
3. rd sample: 2-4 hours after oat consumption
4. th sample: 4-6 hours after oat consumption
5. th sample: 6-9 hours after oat consumption
6. th sample: 9-12 hours after oat consumption
7. th sample: 12-24 hours after oat consumption
8. th sample: 24-32 hours after oat consumption
9. th sample: 48 hours after oat consumption These samples will be analyzed in using HPLC and LC/MS.
日期
最后验证: | 03/31/2020 |
首次提交: | 04/01/2020 |
提交的预估入学人数: | 04/02/2020 |
首次发布: | 04/05/2020 |
上次提交的更新: | 04/02/2020 |
最近更新发布: | 04/05/2020 |
实际学习开始日期: | 01/14/2016 |
预计主要完成日期: | 01/20/2016 |
预计完成日期: | 01/20/2016 |
状况或疾病
干预/治疗
Dietary Supplement: Oat Bran Consumption
相
手臂组
臂 | 干预/治疗 |
---|---|
Experimental: Oat Bran Consumption Each subject consumed 120 g of oat bran (by dry weight) in a single dose, and samples (urine and fecal) were collected at different time points following the administration of oat bran. | Dietary Supplement: Oat Bran Consumption Oat bran (120 g), single dose. |
资格标准
有资格学习的年龄 | 18 Years 至 18 Years |
有资格学习的性别 | All |
接受健康志愿者 | 是 |
标准 | Inclusion Criteria: - BMI 18.5-25 - Have blood and urine biochemical markers in normal range - Have no known allergy to oat relate foods - Be not taking antibiotics for six months - Be not currently taking medication - Be nonsmoking - Have no alcoholic intoxication - Have no extensive exposure to industrial waste Exclusion Criteria: - Individuals with gout - Individuals with heart disease - Individuals with peripheral vascular diseases - Individuals with degenerative liver - Cancer patients - Patients with diabetes - Individuals with GI disorders - Individuals with endocrine disorders |
结果
主要结果指标
1. Bioavailability of Avenanthramides and Saponins in Urine [0-2 hours post-dose]
2. Bioavailability of Avenanthramides and Saponins in Urine [2-4 hours post-dose]
3. Bioavailability of Avenanthramides and Saponins in Urine [4-6 hours post-dose]
4. Bioavailability of Avenanthramides and Saponins in Urine [6-9 hours post-dose]
5. Bioavailability of Avenanthramides and Saponins in Urine [9-12 hours post-dose]
6. Bioavailability of Avenanthramides and Saponins in Urine [12-24 hours post-dose]
7. Bioavailability of Avenanthramides and Saponins in Urine [24-32 hours post-dose]
8. Bioavailability of Avenanthramides and Saponins in Urine [32-48 hours post-dose]