BFRT for Severe Lower Extremity Muscle Atrophy
关键词
抽象
描述
Blood flow restriction training (BFRT) is a safe type of low intensity resistance exercise that has demonstrated enhanced muscle growth, muscle strength, oxygen delivery and utilization (VO2Max). With BFRT, lighter loads can be used to build muscle while sparing the joints from heavy loading and without overly fatiguing the central nervous system.
The objectives of BFRT are 1) to increase the effectiveness of physical therapy, 2) safely increase muscle mass, reduce arterial stiffness, increase bone density, increase Vo2Max, improve carotid arterial compliance and enhance response of the autonomic nervous system, 3) improve muscle endurance in 1/3 the time, improve strength and hypertrophy after surgery, improve muscle recruitment and increase anabolic growth signaling.
日期
| 最后验证: | 03/31/2020 |
| 首次提交: | 04/13/2020 |
| 提交的预估入学人数: | 04/20/2020 |
| 首次发布: | 04/21/2020 |
| 上次提交的更新: | 04/20/2020 |
| 最近更新发布: | 04/21/2020 |
| 实际学习开始日期: | 04/13/2020 |
| 预计主要完成日期: | 04/29/2022 |
| 预计完成日期: | 11/30/2022 |
状况或疾病
干预/治疗
Other: BFRT with 4 exercises and low resistance loads
相
手臂组
| 臂 | 干预/治疗 |
|---|---|
| Experimental: BFRT with 4 exercises and low resistance loads Blood flow resistance training will be performed with a standard blood pressure cuff that is placed and inflated by a clinician. The patient will perform 4 exercises with low resistance loads that will produce a muscle burn to enhance promotion of strength. Training will be supervised in the clinic. The cuff is deflated between exercises. | Other: BFRT with 4 exercises and low resistance loads BFRT is done with 4 exercises with low load resistance of 30% 1 repetition maximum |
资格标准
| 有资格学习的性别 | All |
| 接受健康志愿者 | 是 |
| 标准 | Inclusion Criteria: - Patients with > 20% deficit in isometric quadriceps and/or hamstrings strength - Patients willing to complete at least 9 BFRT training sessions - Patients willing to provide informed consent (or parental consent) Exclusion Criteria: - Pregnancy - History of varicose veins - History of blood clots or active blood clot - Taking oral contraceptives - History of heart attack - Unstable cardiac disease - Taking heart failure medication - Uncontrolled hypertension (> 140/90) - Uncontrolled tachycardia (> 100 bpm) |
结果
主要结果指标
1. Isometric quadriceps and hamstrings muscle strength [Strength will be measured for each patient before training begins and then after 9 training sessions have been completed, for the duration of the study, up to 100 weeks]
次要成果指标
1. Patient rating [The intensity of muscle burn will be determined during each training session. The overall satisfaction will be determined after the last training session for each patient, for the duration of the study, up to 100 weeks.]
