Bioactive Plant Foods: Effects on Functional Bioavailability and Genomic Stability
关键词
抽象
日期
| 最后验证: | 03/31/2017 |
| 首次提交: | 08/19/2009 |
| 提交的预估入学人数: | 08/19/2009 |
| 首次发布: | 08/20/2009 |
| 上次提交的更新: | 04/23/2017 |
| 最近更新发布: | 04/24/2017 |
| 实际学习开始日期: | 05/31/2009 |
| 预计主要完成日期: | 06/30/2010 |
| 预计完成日期: | 11/30/2010 |
状况或疾病
干预/治疗
Dietary Supplement: plant based nutrition bar
相
手臂组
| 臂 | 干预/治疗 |
|---|---|
| Placebo Comparator: placebo Rice powder based nutrition bar | |
| Experimental: Angelica keiskei Angelica keiskei (green leafy vegetable) based nutrition bar | |
| Experimental: Glycine max Glycine max (black soybeans) based nutrition bar | |
| Experimental: Angelica keiskei + Glycine max Angelica keiskei (green leafy vegetable) and glycine max (black soybeans) based nutrition bar |
资格标准
| 有资格学习的年龄 | 50 Years 至 50 Years |
| 有资格学习的性别 | All |
| 接受健康志愿者 | 是 |
| 标准 | Inclusion Criteria: healthy control group (n=20) 1. Age: over 50 years old 2. Female subjects must be post-menopausal 3. BMI: 18.5 - 30, waist/hip ratio < 0.9 for men, < 0.85 for women 4. TG<150 mg/dL (1.7 mmol/L) and no medication for TG 5. Total cholesterol < 200 mg /dL (5.18 mmol/L) and no medication for cholesterol 6. Blood pressure: SBP < 130 mmHg and DBP < 85 mmHg and no hypertensive medication 7. Plasma glucose: fasting blood glucose < 100 mg/dL (5.6 mmol/L) and no diabetes medication Inclusion Criteria: Metabolic syndrome (n=40) 1. Age: over 50 years old 2. BMI: > 30 or waist/hip ratio > 0.9 for men, > 0.85 for women 3. Plus any two of the following four factors: - TG: 150-400 mg/dL (1.7 - 4.52 mmol/L) and/or medication for TG - HDL cholesterol: <40 mg /dL (1.03 mmol/L) for men, <50 mg/dL (1.29 mmol/L) for women and/or medication for cholesterol - Blood pressure: SBP, 130-160 mmHg and/or DBP 85-95 mmHg and/or antihypertensive medication - Plasma glucose: fasting blood glucose 100-125 mg/dL (5.55- 6.94 mmol/L) and no diabetes medication Exclusion Criteria: 1. Study participants will be screened for normal hematologic parameters, normal serum albumin, normal liver function, normal kidney function, absence of fat malabsorption. 2. Subjects with a history of kidney stones, active small bowel disease or resection, atrophic gastritis, insulin-requiring diabetes, alcoholism, pancreatic disease, or bleeding disorders will be excluded from the study. 3. Exogenous hormone users will be excluded from the study. 4. Moreover, subjects will be non-smokers and will not have taken vitamin or carotenoid supplements for at least 6 weeks prior to the study and throughout the study for both healthy subjects and subjects with metabolic syndrome. |
结果
主要结果指标
1. plasma total antioxidant performance, DNA damage and DNA methylation [baseline, 2 & 4 wks after supplementation]
次要成果指标
1. hydrophilic and lipophilic antioxidant nutrients (carotenoids, tocopherols, ascorbic acid and uric acid) [Baseline, 2 & 4 wks after supplementation]
