Biomarkers of Common Eye Diseases
关键词
抽象
描述
The pathogenesis of common eye diseases such as uveitis (including Behcet's disease (BD) and Vogt-Koyanagi-Harada disease (VKH)), diabetic retinopathy (DR), age-related macular degeneration (AMD) and polypoid choroidal vasculopathy (PCV) remains unknown. Although immunosuppressants, anti-vascular endothelial growth factor (VEGF) agents, and pars plana vitrectomy (PPV) have been widely used for treatment, the current therapeutic options are limited. In addition, there is a lack of biomarkers to indicate the prognosis and treatment response of these diseases. The aim of this study is to identify biomarkers and to provide a new target for individualized diagnosis and treatment of common eye diseases based on single cell sequencing technology.
日期
| 最后验证: | 08/31/2019 |
| 首次提交: | 09/19/2019 |
| 提交的预估入学人数: | 09/22/2019 |
| 首次发布: | 09/23/2019 |
| 上次提交的更新: | 09/24/2019 |
| 最近更新发布: | 09/26/2019 |
| 实际学习开始日期: | 09/25/2019 |
| 预计主要完成日期: | 09/30/2020 |
| 预计完成日期: | 09/30/2021 |
状况或疾病
干预/治疗
Other: Collection of blood samples
相
手臂组
| 臂 | 干预/治疗 |
|---|---|
| Patients with VKH, BD, DR, AMD, or PCV Collection of blood samples and clinical information from patients with VKH, BD, DR, AMD, or PCV | |
| Healthy subjects Collection of blood samples and clinical information |
资格标准
| 有资格学习的年龄 | 18 Years 至 18 Years |
| 有资格学习的性别 | All |
| 取样方式 | Non-Probability Sample |
| 接受健康志愿者 | 是 |
| 标准 | Inclusion Criteria for patients: 1. Age over 18 (including 18 years old); 2. Clinically diagnosed as diabetic retinopathy (DR), uveitis (VKH or BD) , age-related macular degeneration (AMD) , or polypoid choroidal vasculopathy (PCV) Exclusion Criteria for patients with retinal diseases: 1. Have received more than 2 intravitreal injections of anti-VEGF drugs because of retinal or choroidal neovascularization and macular edema; 2. Patients with stable condition after having undergone panretinal laser photocoagulation and pars plana vitrectomy (PPV); 3. There are other serious systemic diseases of the body, such as history of chronic kidney disease requiring dialysis or a kidney transplant, unstable blood pressure, cardiovascular disease, tumors, etc; 4. Patients who are pregnant or nursing |
结果
主要结果指标
1. Peripheral blood mononuclear cell (PBMC) signatures [1 year]
次要成果指标
1. PBMC cell types frequencies [1 year]
