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Body Composition and White Adipose Tissue Inflammation

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状态招聘中
赞助商
Memorial Sloan Kettering Cancer Center
合作者
Weill Medical College of Cornell University

关键词

抽象

The investigators want to find a better way to predict the risk of having fatty tissue inflammation by using a different approach to finding out body fat composition. In this study, the investigators want to estimate the body fat composition using a DEXA scan. DEXA stands for dual energy X-ray absorptiometry. It is the standard and established test to determine bone mineral density (how strong the bones are) to diagnose osteoporosis. This test can also be used to determine the body composition including percent body fat and lean mass. The investigators will compare the participants DEXA scan results for body fat composition to the inflammation found in the breast tissue from the mastectomy to see if there is a relationship. If successful, this may help us predict which patients may be at risk for breast cancer in the future. In addition, the investigators will compare the participants DEXA scan results for body fat composition and inflammation found in the fat tissue from the mastectomy or prostatectomy to the level of exercise activity as measured by a short questionnaire to see if there is a relationship. The investigators will also measure the participants waist to hip ratio.
Finally, at the time the participant has blood drawn for their standard presurgical testing, the investigators will also test the blood for prediabetes using a blood test called hemoglocin A1c. The investigators will also measure for the participants waist to hip ratio, and a Hgb A1c blood drawn will be take at the time of presurgical testing. If not feasible, Hgb A1c can be drawn at a separate visit prior to the DEXA scan. If successful, this may help us predict which patients may be at risk for breast cancer in the future.

日期

最后验证: 03/31/2020
首次提交: 03/10/2016
提交的预估入学人数: 03/14/2016
首次发布: 03/17/2016
上次提交的更新: 04/06/2020
最近更新发布: 04/07/2020
实际学习开始日期: 11/03/2015
预计主要完成日期: 10/31/2021
预计完成日期: 10/31/2021

状况或疾病

Breast Cancer
Prostate Cancer
Body Composition
White Adipose Tissue Inflammation

干预/治疗

Device: DEXA Scan

Behavioral: Godin Leisure Time Exercise Questionnaire (GLTEQ)

-

手臂组

干预/治疗
Breast Cancer
DEXA scan will be carried out 1 to 30 days prior to mastectomy. Patients will also complete the Godin Leisure Time Exercise Questionnaire (GLTEQ) and their waist to hip ratio will be measured.
Prostate Cancer
DEXA scan will be carried out 1 to 30 days prior to radical prostatectomy. Patients will also complete the Godin Leisure Time Exercise Questionnaire (GLTEQ) and their waist to hip ratio will be measured.

资格标准

有资格学习的年龄 18 Years 至 18 Years
有资格学习的性别All
取样方式Non-Probability Sample
接受健康志愿者
标准

Inclusion Criteria:

- Age ≥ 18

- Female

- All BMIs

- Patients undergoing mastectomy at MSKCC (i.e. Nipple-sparing mastectomy, skin-sparing mastectomy, simple mastectomy, modified radical mastectomy, radical mastectomy); mastectomy may be either prophylactic or therapeutic. OR

- Patients undergoing hysterectomy at MSKCC

- History of prior breast surgeries/procedures is acceptable

Exclusion Criteria:

- Pregnancy (confirmed or suspected);

- Inability to lay supine on equipment table and maintain the position for the necessary time;

- Weight superior to the maximum allowed by the DEXA machine (over 350 lbs or 158 kg);

- Greater than 10% baseline weight loss in the past year;

- Planned surgical procedure is not a Mastectomy (i.e. breast conservation surgery or other non-mastectomy procedure; such as lumpectomy) or hysterectomy

- Metastatic cancer

- History of Wasting Syndromes or Cachexia

- Use of daily NSAIDs, aspirin, or steroids (other than inhaled or topical) within 30 days of surgery

- Use of neoadjuvant systemic or radiation therapy.

结果

主要结果指标

1. fat percentage [1 year]

as measured by DEXA

2. presence of White Adipose Tissue Inflammation (WATi ) [1 year]

as measured by DEXA

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