Coffee Polyphenols Antioxidants
关键词
抽象
描述
This is an interventional study with a crossover randomized placebo-controlled double-blind design to assess the effect of regular consumption of coffee on oxidative stress compared to placebo.
日期
| 最后验证: | 03/31/2014 |
| 首次提交: | 04/07/2013 |
| 提交的预估入学人数: | 04/10/2013 |
| 首次发布: | 04/15/2013 |
| 上次提交的更新: | 04/16/2014 |
| 最近更新发布: | 04/20/2014 |
| 实际学习开始日期: | 02/28/2011 |
| 预计主要完成日期: | 03/31/2012 |
| 预计完成日期: | 05/31/2013 |
状况或疾病
干预/治疗
Other: coffee
Other: coffee polyphenols mixed with placebo
Other: maltodextrin enriched with caffeine
相
手臂组
| 臂 | 干预/治疗 |
|---|---|
| Experimental: Coffee 4 cups/day of 2.5g of coffee each | |
| Active Comparator: coffee polyphenols mixed with placebo 4 cups/day of 2.5g of product each | |
| Placebo Comparator: maltodextrin enriched with caffeine 4 cups/day of 2.5g of product each |
资格标准
| 有资格学习的年龄 | 20 Years 至 20 Years |
| 有资格学习的性别 | All |
| 接受健康志愿者 | 是 |
| 标准 | Inclusion Criteria: - 20 - 70 years, male and female - healthy - BMI 19 - 29 kg/m2 - Coffee drinkers with an average consumption of 1-3 cups per day - having given informed consent Exclusion Criteria: - Intestinal or metabolic diseases / disorders such as diabetic, renal, hepatic, hypertension, pancreatic or ulcer- Have had a gastrointestinal surgery, except appendicectomy - Difficulty to swallow - Have a regular consumption of medication - Have taken antibiotic therapy within the last 6 months - Alcohol consumption > 2 units a day - Smokers (more than 5 cigarettes per day) - Have given blood within the last 3 weeks - Volunteers who cannot be expected to comply with treatment - Currently participating or having participated in another clinical trial during the last 3 weeks |
结果
主要结果指标
1. oxidative stress [Change in plasma and in urine beta isoprostane from baseline to the last day of a 10-day period of product intake]
次要成果指标
1. bioavailability of coffee phenolics [Change of plasma chrorogenic and phenolic acids from baseline to the last day of a 10-day period of product intake]
