Cognitive Impairment, Retinopathy, and Cerebrovascular Lesions in the Elderly
关键词
抽象
描述
Cerebral small vessel disease (SVD) is commonly detected in elderly individuals, and patients with stroke or neurodegenerative disease. Features seen on neuroimaging include recent small subcortical infarcts, lacunes, white matter hyperintensities, perivascular spaces, microbleeds, and brain atrophy. Previous studies indicated that SVD was associated with an increased risk of stroke and stroke recurrence, cognitive deficits, physical disabilities, and mortality. However the pathogenesis of SVD is largely unknown. Little is known about how SVD lesions contribute to neurological or cognitive symptoms, and the association with risk factors. Recent data sugessted concomitant SVDs and retinopathy is associated with a profile of vascular cognitive impairment. In this study, the investigators try to explore the new pathological mechanism of SVD, the new predictors for SVD progression, and the association with cognitive Impairment, based on digital retinal images and brain multimodal imaging technique.
日期
最后验证: | 02/29/2020 |
首次提交: | 05/19/2018 |
提交的预估入学人数: | 05/19/2018 |
首次发布: | 05/30/2018 |
上次提交的更新: | 03/28/2020 |
最近更新发布: | 03/30/2020 |
实际学习开始日期: | 04/29/2017 |
预计主要完成日期: | 05/29/2027 |
预计完成日期: | 05/29/2027 |
状况或疾病
干预/治疗
Other: multimodal magnetic resonance imaging
相
手臂组
臂 | 干预/治疗 |
---|---|
Individuals with SVDs Individuals with at least one following imaging finding: recent small subcortical infarcts, lacunes, white matter hyperintensities, perivascular spaces, microbleeds, or brain atrophy on baseline brain MRI. | |
Individuals without SVDs Individuals without any following imaging finding: recent small subcortical infarcts, lacunes, white matter hyperintensities, perivascular spaces, microbleeds, or brain atrophy on baseline brain MRI. |
资格标准
有资格学习的年龄 | 40 Years 至 40 Years |
有资格学习的性别 | All |
取样方式 | Non-Probability Sample |
接受健康志愿者 | 是 |
标准 | Inclusion Criteria: - Adult (≥40y; no upper limit) - Free of known dementia or stroke (both cerebral infarction and hemorrhage) Exclusion Criteria: - Any MRI contraindications - Serious head injury (resulting to loss of consciousness) or received intracranial surgery - Suffering from cancer |
结果
主要结果指标
1. Cognitive state [1year]