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Comparative Study of Three Common Bile Duct Closure Techniques

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South Valley University

关键词

抽象

this study evaluate the efficacy and safety of three different methods of CBD repair and provide more evidence for selecting the optimal duct closure after choledocholithotomy.

描述

At present, the commonest available options for CBD closure include repair over T-tube drain, primary closure and repair after antegrade biliary stenting. All three methods present specific technical performance features, require different postoperative management protocols, and are charged with specific morbidity related to the procedure and therefore should not be considered exactly the same procedure in the context of LCBDE.

Repair over T-tube is the traditional surgical technique. It has many advantages as post-operative distal CBD decompression, trans-tubal cholangiography, and availability of retained CBD stones extraction. However, it has a number of potential complications up to 10% of patients. The most frequent complications are bile leakage, tract infection, T-tube dislodgement, electrolyte and nutritional disturbances, cholangitis, or acute renal failure from dehydration due to inadequate water ingestion. It also causes discomfort and persistent pain to the patient along with increased hospital admission and thus economic burden to the country. Primary closure of CBD has been described in literature to overcome these adverse consequences of the T-tube. However, it has a number of potential complications as a potential bile leak and CBD stricture which may occur owing to papillary edema and insufficient bile duct expansion. There are conflicting results regarding significant differences in the morbidity and mortality between primary closure and T-tube drainage. There is no conclusive evidence displaying whether primary closure is better or worse than T-tube drainage after CBD exploration.

In order to decrease the two complications, using biliary stent in primary closure is an effective method, which can reduce biliary pressure without bile loss. Although, there are some available drainage options after LCBDE, a consensus on the optimal drainage is yet to be reached.

日期

最后验证: 03/31/2020
首次提交: 02/06/2020
提交的预估入学人数: 02/06/2020
首次发布: 02/10/2020
上次提交的更新: 04/02/2020
最近更新发布: 04/06/2020
实际学习开始日期: 12/31/2016
预计主要完成日期: 12/31/2019
预计完成日期: 06/30/2020

状况或疾病

Common Bile Duct Closure

干预/治疗

Procedure: T tube drainage

Procedure: Primary closure

Procedure: Antegrade stenting

-

手臂组

干预/治疗
Active Comparator: T tube drainage
Closure of common bile duct after choledocholithotomy over T tube
Experimental: Primary closure
Primary closure of the common bile duct after choledocholithotomy
Experimental: Antegrade stenting
Closure of common bile duct over antegrade biliary plastic stent

资格标准

有资格学习的年龄 20 Years 至 20 Years
有资格学习的性别All
接受健康志愿者
标准

Inclusion criteria

- CBD stones

- age from 20 to 80,

- CBD > 0.8 cm and < 2.5 cm,

- American Society of Anesthesiologists (ASA) grade I, II or III,

- agreement to randomization and complete the study requirement. Exclusion criteria

- acute suppurative cholangitis,

- acute biliary pancreatitis,

- biliary malignancy,

- biliary malformation,

- distal CBD stenosis and or obstruction,

- trans-cystic stone extraction,

- explorations followed by choledochojejunostomy and choledochoduodenostomy.

结果

主要结果指标

1. Perioperative morbidity [30 days]

postoperative biliary complication

2. Perioperative mortality [10 days]

Patient who died from any reason before discharge

次要成果指标

1. Wound infection [10 days]

Wound requiring partial or complete opening for drainage, including T-tube tract infection

2. Persistent biliary fistula [30 days]

Failed spontaneous closure of biliary fistula

3. Operative time [2 Hours]

the length of operation from starting anesthesia up to recovery

4. Hospital stay [4 days]

the length of hospital admission from patient admission up to postoperative discharge

5. CBD stricture [6 month]

Post operative narrowing of CBD

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