Consequence of Lifetime Isolated Growth Hormone Deficiency
关键词
抽象
描述
SPECIFIC AIM 1: To study anthropometric parameters, cardiovascular and metabolic status and cardiovascular risk profile, including inflammatory markers of cardiovascular relevance, muscle strength, bone density and bone metabolism, and thyroid status of twenty GH-naïve adult GHD subjects who are homozygous for a null GHRHR mutation and to compare them with twenty age- and sex- matched normal controls from the same population.
SPECIFIC AIM 2: To observe the changes in all the above parameters that occur in GHD subjects after a 6-months treatment with hGH replacement, and their reversibility after a 6-months washout period.
SPECIFIC AIM 3: To determine effect of heterozygosity for the GHRHR mutation. To this end, we propose to genotype a large number of apparently normal members of the Itabaianinha community with the goal of separating subjects homozygous for the wild-type allele from subjects heterozygous for the GHRHR mutation, and to compare their phenotype with the one observed in subjects homozygous for the wild type allele residing in the same geographical area.
Together, these studies will determine the effect of lifetime absence of GH on multiple organ functions and their response to hGH therapy, and will tell if heterozygosity for mutations in the GHRHR gene is associated with a detectable phenotype.
日期
最后验证: | 05/31/2010 |
首次提交: | 09/05/2005 |
提交的预估入学人数: | 09/06/2005 |
首次发布: | 09/07/2005 |
上次提交的更新: | 06/12/2010 |
最近更新发布: | 06/14/2010 |
实际学习开始日期: | 08/31/2005 |
预计主要完成日期: | 11/30/2009 |
预计完成日期: | 11/30/2009 |
状况或疾病
干预/治疗
Drug: growth hormone administration for 6 months
相
资格标准
有资格学习的年龄 | 18 Years 至 18 Years |
有资格学习的性别 | All |
接受健康志愿者 | 是 |
标准 | Inclusion Criteria: - Lifetime isolated and untreated growth hormone deficiency Exclusion Criteria: - Age below 18 years, pregnancy, diabetes |
结果
主要结果指标
1. Body composition [after 6 months of GH and after wash out (6 and 12 months)]
2. Lipid levels [after 6 months of GH and after 6 and 12 months of wash out]
3. Heart function [after 6 months of GH and after 6 and 12 months of wash out]