Decoding Presymptomatic White Matter Changes in Huntington Disease
关键词
抽象
日期
| 最后验证: | 01/31/2020 |
| 首次提交: | 06/12/2017 |
| 提交的预估入学人数: | 06/18/2017 |
| 首次发布: | 06/19/2017 |
| 上次提交的更新: | 02/16/2020 |
| 最近更新发布: | 02/17/2020 |
| 实际学习开始日期: | 07/10/2017 |
| 预计主要完成日期: | 12/29/2019 |
| 预计完成日期: | 12/29/2019 |
状况或疾病
干预/治疗
Other: Brain imaging
Other: Neurological assessments
Behavioral: Psychological assessments
Behavioral: Behavioural assessments
相
手臂组
| 臂 | 干预/治疗 |
|---|---|
| Other: Premanifest HTT mutation carriers | |
| Other: non HTT mutation carriers |
资格标准
| 有资格学习的年龄 | 18 Years 至 18 Years |
| 有资格学习的性别 | All |
| 接受健康志愿者 | 是 |
| 标准 | Inclusion Criteria: - For presymptomatic individuals: - Genetic test available with CAG (Cytosine-Adenine-Guanine) repeat length > 36 in HTT gene - UHDRS score <5 - Burden score <250 - For controls: - Genetic test available with CAG repeat length ≤ 36 in HTT gene - Common inclusion criteria for presymptomatic individuals and controls (age-matched and gender-matched with presymptomatic individuals and but without any familial relationship): - At least 18 years of age - Capacity to consent - Signature of the informed consent - Covered by social security - Ability to undergo MRI scanning Non-Inclusion Criteria: - Under the age of 18 years of age - Contra-indications to MRI examination (metallic implant, pacemaker, artificial heart valve, brain vascular malformation, aneurysm clips, exposed by metallic fragments, artificial implants, peripheral or neuronal stimulator, insulin pump, intravenous catheter, epilepsy, person with an history of seizure, metallic contraceptive device, permanent eyelid make up, claustrophobia,…) - Unwillingness to be informed in case of abnormal MRI (with a significant medical anomaly) - History of severe head injury - History of neurological disorder or presence of neurological disorder - Participation in a drug trial or exclusion period of another study - Pregnancy or breastfeeding - Inability to understand information about the protocol - Person deprived of their liberty by judicial or administrative decision - Person under legal protection (legal guardianship, tutelage or maintenance of justice) - Person without any protection and unable to consent |
结果
主要结果指标
1. Detection by Diffusion-weighted spectroscopy of abnormal white matter changes prior to the onset of Huntington disease comparing HTT mutation carriers and non HTT mutation carriers over one year [one year]
次要成果指标
1. Detection by Diffusion-weighted spectroscopy of abnormal white matter changes over one year as an intersubject evolution [one year]
2. Detection by Diffusion Tensor Imaging of abnormal white matter changes prior to the onset of Huntington disease comparing HTT mutation carriers and non HTT mutation carriers over one year. [one year]
3. Detection by Diffusion Tensor Imaging white matter changes over one year as an intersubject evolution. [one year]
4. Detection of abnormal scores from psychological tests to assess possible early non motor changes and their intersubject evolution over one year. [one year]
5. Detection of choice rates and time differences in the behavioral task comparing HTT mutation carriers and non HTT mutation carriers over one year. [one year]
6. Detection of time differences in the behavioral task comparing HTT mutation carriers and non HTT mutation carriers over one year. [one year]
