Determination of Glycemic and Insulinemic Indices
关键词
抽象
日期
最后验证: | 10/31/2011 |
首次提交: | 10/03/2011 |
提交的预估入学人数: | 11/17/2011 |
首次发布: | 11/21/2011 |
上次提交的更新: | 11/17/2011 |
最近更新发布: | 11/21/2011 |
实际学习开始日期: | 12/31/2002 |
预计主要完成日期: | 11/30/2008 |
预计完成日期: | 11/30/2013 |
状况或疾病
干预/治疗
Other: ELSA 1-9
相
手臂组
臂 | 干预/治疗 |
---|---|
Experimental: Measuring method To compare glycemic responses and GI values from capillary and venous blood and to compare glucose solution with white bread as the reference food and to study the effect of the number of reference tests on GI values. | |
Experimental: Mixed meals To examine the glycaemic and insulinaemic responses of a mashed potato-based meal when a high fat food (rapeseed oil) or a high protein food (chicken breast) or fat, protein and salad together were added to the meal. Furthermore, we studied how the predicted and measured GI values of the mixed meal differed from each other. | |
Experimental: Coffee To examine the effects of two different coffee portions with glucose and caffeine-containing soft drinks on postprandial glucose and insulin responses. Further objectives were to study how coffee and different accompaniments affect glucose and insulin responses. | |
Experimental: Snacks To measure GI and II values for Finnish snack foods | |
Experimental: Berries To study the effects of berries on glycemic and insulinemic responses | |
Experimental: GIs of low-carbs To measure glycemic and insulinemic responses to low-carbohydrates foods | |
Experimental: Glucose metabolism and BMI To examine the effects of overweight and glucose tolerance on the glucose, insulin and lipid responses to an HGI meal and an LGI meal. Furthermore, the second aim was to study the effect of BMI and glucose tolerance on the GI measured. | |
Experimental: Insulin measurement To compare how methodological choices affect measured insulin values | |
Experimental: Alcohol To investigate the effect of alcohol on postprandial glucose and insulin responses, and to determine glycemic and insulinemic indices values for beer and non-alcoholic beer. |
资格标准
有资格学习的年龄 | 20 Years 至 20 Years |
有资格学习的性别 | All |
接受健康志愿者 | 是 |
标准 | Inclusion Criteria: - For Studies 1-9 a total of 12 to 24 volunteers per study with a normal glucose tolerance based upon a 2 h 75g oral glucose tolerance test (OGTT). - For Study 7 a total of 24 volunteers with impaired glucose tolerance based on an OGTT. - For Studies 1-6 and 8-9 with an age of 20 to 60 and with a BMI of 18 to 30 kg/m2. - For Study 7 an age of 62 to 72 and with a BMI of 20 to 35 kg/m2. Exclusion Criteria: - First-degree family history of diabetes - An active gastrointestinal or metabolic disease - For Studies 1-6 and 8-9 chronic medication (oral contraceptives were allowed) - For Study 7 regular medication that would have affect glucose and lipid metabolism - Smoking - Pregnancy - Breastfeeding - History of polycystic ovary syndrome - History of gestational diabetes |
结果
主要结果指标
1. Glucose [2 to 5 hours]
2. Insulin [2 to 5 hours]
3. Free fatty acids [2 to 5 hours]
4. Triglyserides [2 to 5 hours]
次要成果指标
1. IGF1 [2 to 5 hours]
2. Satiety [2 to 5 hours]
3. IGF-BP1 [2 to 5 hours]