Dexmedetomidine Addition to Morphine in Patients With Metastatic Cancer
关键词
抽象
日期
| 最后验证: | 04/30/2019 |
| 首次提交: | 04/30/2019 |
| 提交的预估入学人数: | 04/30/2019 |
| 首次发布: | 05/02/2019 |
| 上次提交的更新: | 05/10/2019 |
| 最近更新发布: | 05/13/2019 |
| 实际学习开始日期: | 07/31/2016 |
| 预计主要完成日期: | 09/30/2017 |
| 预计完成日期: | 09/30/2017 |
状况或疾病
干预/治疗
Drug: Dexmedetomidine
相
手臂组
| 臂 | 干预/治疗 |
|---|---|
| No Intervention: Control | |
| Experimental: Dexmedetomidine | Drug: Dexmedetomidine Patients allocated to this group receive a combination of Morphine and Dexmedetomidine |
资格标准
| 有资格学习的年龄 | 18 Years 至 18 Years |
| 有资格学习的性别 | All |
| 接受健康志愿者 | 是 |
| 标准 | Inclusion Criteria: - Any painful patient with metastatic cancer - Whatever type of pain: nociceptive, neuropathic, or mixed - Age > 18 and <75 years - Patient under analgesic Tier III treatment: with moderate to severe pain and not relieved by non-opioid conventional treatment - Patient cooperating capable of responding to the pain assessment by providing a number from 0 to 10 at the VAS - Patient providing his explicit consent to participate in the study before inclusion (regardless of his inclusion in C or D Group) - Patients with systolic blood pressure (SBP) ≥ 100 mmHg and a diastolic blood pressure (DBP) ≥ 50 mmHg - Patients with a heart rate ≥ 50/min Exclusion Criteria: - Patient refusal to participate in the study or patient unable to give consent - Age <18 or > 75 years - Comatose uncooperative patient unable to respond to the assessment of pain by VAS - Hypotensive patients with SBP < 100 mmHg and DBP < 60 mmHg or bradycardic with a heart rate < 50/min - Patient with a heart rhythm disorder, or a disorder of the atrial-ventricular conduction - Patients under beta-blocker - Patient with heart failure with an ejection fraction < 40% - Patient suffering from allergy or previous intolerance to morphine or dexmedetomidine - Patient with renal impairment with a creatinine clearance <3 0ml/min/1.73m2, or patient under hemodialysis or peritoneal dialysis. - Patient with severe hepatic impairment with Child-Pugh score at C. |
结果
主要结果指标
1. Pain score [48 hours]
2. Morphine consumption [48 hours]
